Autonomic and Cytokines Profiles of Patients With Ulcerative Proctitis
| Status: | Recruiting |
|---|---|
| Conditions: | Irritable Bowel Syndrome (IBS), Gastrointestinal |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 11/3/2018 |
| Start Date: | November 30, 2017 |
| End Date: | July 31, 2019 |
| Contact: | Jiande Chen, PhD |
| Email: | jchen184@jhmi.edu |
| Phone: | 832-640-8111 |
1. To prove that patients with ulcerative proctitis and proctosigmoiditis have impaired
autonomic functions, i.e. increased sympathetic activity and/or reduced vagal tone.
2. To demonstrate inflammatory cytokine imbalance, i.e., increased pro-inflammatory
cytokines. Presence of these abnormalities would make patients with ulcerative proctitis
and proctosigmoiditis good candidates for future sacral nerve stimulation therapy.
autonomic functions, i.e. increased sympathetic activity and/or reduced vagal tone.
2. To demonstrate inflammatory cytokine imbalance, i.e., increased pro-inflammatory
cytokines. Presence of these abnormalities would make patients with ulcerative proctitis
and proctosigmoiditis good candidates for future sacral nerve stimulation therapy.
Inclusion Criteria:
- No any systemic diseases;
- no proctitis or proctosigmoiditis;
- no history of gastrointestinal surgery;
- no symptoms of diarrhea or fecal urgency during the past 2 weeks;
- not taking any medications except contraceptives during the past 2 weeks;
- age 18-65.
Exclusion Criteria:
We found this trial at
1
site
3400 N Charles St
Baltimore, Maryland 21205
Baltimore, Maryland 21205
410-516-8000
Phone: 832-640-8111
Johns Hopkins University The Johns Hopkins University opened in 1876, with the inauguration of its...
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