Vitamin C to Reduce Morning Cardiovascular Risk
| Status: | Recruiting |
|---|---|
| Conditions: | Peripheral Vascular Disease |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 40 - 60 |
| Updated: | 2/8/2019 |
| Start Date: | February 13, 2018 |
| End Date: | December 30, 2019 |
| Contact: | Saurabh S Thosar, PhD |
| Email: | thosar@ohsu.edu |
| Phone: | 5034942064 |
Chronotherapeutic Use of Vitamin C to Reduce Morning Cardiovascular Risk
This study will test the efficacy of Vitamin C to counteract morning CV risk markers in a
randomized, double blind, placebo controlled crossover pilot study. The participants will
also perform morning typical behaviors such as arousal from sleep, change in posture (getting
out of bed) and mild intensity physical activity; identical to the stressors encountered in
everyday life. Primary dependent variables are markers of cardiovascular risk including
vascular endothelial function and oxidative stress.
randomized, double blind, placebo controlled crossover pilot study. The participants will
also perform morning typical behaviors such as arousal from sleep, change in posture (getting
out of bed) and mild intensity physical activity; identical to the stressors encountered in
everyday life. Primary dependent variables are markers of cardiovascular risk including
vascular endothelial function and oxidative stress.
The investigators plan to test the efficacy of Vitamin C to counteract morning CV risk
markers in a randomized, double blind, placebo controlled crossover pilot study. The
participants will also perform morning typical behaviors such as arousal from sleep, change
in posture (getting out of bed) and mild intensity physical activity; identical to the
stressors encountered in everyday life. This pilot study is in healthy middle aged adults
without a history of CV disease.
Participants will spend two nights in an inpatient hospital suite at Hatfield Research
Center. Upon awakening in the morning, they will either ingest Vitamin C or placebo in a
randomized order. This will be followed by moderate intensity exercise, recovery, and
discharge.
markers in a randomized, double blind, placebo controlled crossover pilot study. The
participants will also perform morning typical behaviors such as arousal from sleep, change
in posture (getting out of bed) and mild intensity physical activity; identical to the
stressors encountered in everyday life. This pilot study is in healthy middle aged adults
without a history of CV disease.
Participants will spend two nights in an inpatient hospital suite at Hatfield Research
Center. Upon awakening in the morning, they will either ingest Vitamin C or placebo in a
randomized order. This will be followed by moderate intensity exercise, recovery, and
discharge.
Inclusion Criteria:
- Healthy participants
- Normal weight or overweight but not obese (18.5
Exclusion Criteria:
- History of smoking/tobacco use
- Current prescription/non-prescription medications or drugs of abuse
- Acute, chronic, or debilitating medical conditions
- History of working irregular day and night hours, regular night work, or rotating
shift work for the six months prior to the study.
We found this trial at
1
site
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
Portland, Oregon 97239
503 494-8311
Phone: 503-494-2064
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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