Remote Ischemic Preconditioning in ACS Patients
| Status: | Recruiting |
|---|---|
| Conditions: | Peripheral Vascular Disease, Renal Impairment / Chronic Kidney Disease, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Nephrology / Urology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 8/3/2018 |
| Start Date: | October 26, 2016 |
| End Date: | August 30, 2019 |
| Contact: | Brittany Fuller, MD |
| Email: | bfuller1@hfhs.org |
| Phone: | (313) 352-1177 |
Remote ischemic preconditioning is a process of serial blood pressure cuff inflations and
deflations that are performed prior to a procedure and have been shown in various other areas
(coronary bypass surgery, vascular surgery, ST elevation myocardial infarctions) to decrease
the rates of adverse events related to ischemic burden and renal injury. This procedure has
not yet been studied in the population presenting with an acute coronary syndrome (ACS), even
though ACS patients represent the majority of patients seen in the catheterization lab. The
purpose of this study is to evaluate the efficacy of this simple and safe procedure in this
particular population.
deflations that are performed prior to a procedure and have been shown in various other areas
(coronary bypass surgery, vascular surgery, ST elevation myocardial infarctions) to decrease
the rates of adverse events related to ischemic burden and renal injury. This procedure has
not yet been studied in the population presenting with an acute coronary syndrome (ACS), even
though ACS patients represent the majority of patients seen in the catheterization lab. The
purpose of this study is to evaluate the efficacy of this simple and safe procedure in this
particular population.
Inclusion Criteria:
- Presenting with an acute coronary syndrome including non-ST elevation myocardial
infarction or unstable angina on optimal medical therapy with aspirin, P2Y12 inhibitors,
unfractionated heparin, statin, +/- beta blocker, +/- ace inhibitor
Exclusion Criteria:
- Presenting with ST elevation myocardial infarction
- Patients requiring circulatory support
- Need for emergent percutaneous coronary intervention
- Systemic hypotension (systolic blood pressure <90 mmHg)
- Patients in cardiogenic shock defined by requiring inotropes or vasopressors
- Patients currently on hemodialysis
- Presence of an arteriovenous dialysis fistula or graft or lymphedema in either arm
- Patients enrolled in other active cardiovascular investigational studies
- Severe comorbidities with a life expectancy of less than 6 months
- Pregnant or lactating women
- Patients unable to provide consent
- Patient taking the medication glibenclamide for treatment of diabetes
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Henry Ford Hospital Founded in 1915 by auto pioneer Henry Ford and now one of...
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