Advanced MR Imaging in Sarcoma Patients
| Status: | Recruiting |
|---|---|
| Conditions: | Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 7 - Any |
| Updated: | 10/17/2018 |
| Start Date: | March 2016 |
| End Date: | January 2021 |
| Contact: | Clinical Trials Referral Office |
| Phone: | 855-776-0015 |
A Pilot Study of the Utility of Perfusion MRI and MR Elastography for Surgical Planning, Radiotherapy Target Delineation, and Treatment Response Evaluation in Newly Diagnosed Ewing Sarcoma, Rhabdomyosarcoma and Soft Tissue Sarcoma Patients
We intend to investigate the clinical application of two emerging imaging modalities for
which the technical capability is currently in place at Mayo Clinic. The treatment of Ewing
Sarcoma (ES), Rhabdomyosarcoma (RMS) and soft tissue sarcoma (STS) patients on this study
will involve multi-disciplinary contributions from nationally recognized sarcoma experts in
Radiation Oncology, Radiology, Orthopedic Surgery, Pediatric Oncology, Medical Oncology and
Pathology.
Patients will undergo additional magnetic resonance (MR) imaging at the same time as the
standard imaging.
The ability to compare several imaging modalities within a single cohort of patients
maximizes the potential of the study to impact the future management of sarcoma patients. The
collaborative nature of this study, with essential contributions from many departments will
undoubtedly improve the coordinated care of sarcoma patients and naturally disseminate the
advanced imaging experience that is acquired.
which the technical capability is currently in place at Mayo Clinic. The treatment of Ewing
Sarcoma (ES), Rhabdomyosarcoma (RMS) and soft tissue sarcoma (STS) patients on this study
will involve multi-disciplinary contributions from nationally recognized sarcoma experts in
Radiation Oncology, Radiology, Orthopedic Surgery, Pediatric Oncology, Medical Oncology and
Pathology.
Patients will undergo additional magnetic resonance (MR) imaging at the same time as the
standard imaging.
The ability to compare several imaging modalities within a single cohort of patients
maximizes the potential of the study to impact the future management of sarcoma patients. The
collaborative nature of this study, with essential contributions from many departments will
undoubtedly improve the coordinated care of sarcoma patients and naturally disseminate the
advanced imaging experience that is acquired.
Inclusion Criteria:
- Age ≥ 7 years.
- Histological confirmation of newly diagnosed localized or newly diagnosed with
metastatic Ewing Sarcoma, Rhabdomyosarcoma or Soft tissue Sarcoma.
- Tumors > 5 cm in diameter.
- Planning to receive RT or surgery with or without adjuvant radiotherapy (RT) at Mayo
Clinic Rochester.
- Provide informed written consent if ≥ 18 years. If < 18 years, provide informed
written assent and parent or legal guardian provide informed written consent.
- Patients must have measurable disease as defined in Section 11.0.
- Willingness to participate in mandatory imaging studies at Mayo Clinic Rochester.
- Baseline MRE information deemed as acceptable for assessment
- Baseline perfusion MRI deemed as acceptable for assessment
Exclusion Criteria:
- Co-morbid conditions that would result in expected survival to be less than 5 years
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