Pharmacogenetic Testing in Children With Persistent Gastroesophageal Reflux Disease

This study will assess the clinical utility of pharmacogenomics testing in the clinical
management of children with refractory GERD, despite adequate therapy and the role of
pharmacogenomics in selecting the right acid suppressive therapy based on each patient's
symptoms and pharmacogenomics results.

Inclusion Criteria:

- persistent gastrointestinal symptoms (GI) suggestive of gastro esophageal reflux
disease (GERD) despite adequate therapy

- persistent evidence of abnormal reflux indices' and acid exposure on esophageal
multichannel pH impedance study despite adequate therapy

- persistent endoscopic evidence of reflux esophageal disease despite adequate therapy

Exclusion Criteria:

- children with eosinophilic esophagitis diagnosis

- children with any esophageal surgical intervention like fundoplication,
tracheoespahgeal fistula repair or esophageal atresia repair

- children with other diseases that can affect the esophagus, like Crohn's disease or
food protein-induced enterocolitis syndrome (F-PIES)

- Children who do not have research authorization in their chart