Bone Marrow Aspirate Compared to Platelet Rich Plasma for Treating Knee Osteoarthritis

While PRP shows promise in helping restore function to these patients, there are still
concerns with PRP's long term outcomes. Another option that has become more popular for
physicians treating this debilitation condition is bone marrow aspirate concentrate (BMA),
which use's undifferentiated cells found in the bone marrow to promote healing and tissue
regeneration. These cells have the ability to replicate into a multiple different tissue
types. With BMA, the marrow is concentrated provide better healing of the damaged tissue and
aid in growth and repair. The full benefits of BMA are still unknown, but studies have shown
the treatment can reduce swelling, relieve pain, and improve healing in articular cartilage
and bone grafts.

Autologous BMA has shown promising clinical potential as a therapeutic agent in regenerative
medicine, including the treatment of osteoarthritis and cartilage defects, and the clinical
efficacy platelet rich plasma has been documented to alleviate symptoms related to knee
osteoarthritis. However, randomized, prospective comparison of the two techniques has not
been reported in the literature and long term follow-up for both treatments is limited, and
especially limited in the use of BMA for osteoarthritis treatment.

Inclusion Criteria:

- Male or female age 18-80 years

- Knee osteoarthritis

- Subjects must present with pain or swelling to target knee for at least 4 months

- Kellgren-Lawrence score between 1 and 3 upon x-ray evaluation

- Must be willing and able to provide informed consent

- Willing and able to return for scheduled follow-up visits

Exclusion Criteria:

- Major mechanical axis deviation of more than 50% into either compartment (varus or
valgus )

- Have had a corticosteroid injection within 3 months or a hyaluronic acid injection
within 6 months

- History of the following medical conditions:

- diabetes

- autoimmune disorders

- disorders requiring immunosuppression

- rheumatoid arthritis

- hemophilic arthropathy

- infectious arthritis

- Charcot's knee

- Paget's disease of the femur or tibia

- Cancer

- Ongoing infectious disease

- Significant cardiovascular, renal or hepatic disease