Non-contrast MR Imaging for Whole Body Cancer Detection and Characterization
| Status: | Recruiting |
|---|---|
| Conditions: | Prostate Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 2/23/2018 |
| Start Date: | March 24, 2016 |
| End Date: | January 1, 2021 |
| Contact: | Candace Winkler, MS |
| Email: | cmwinkler@ucsd.edu |
| Phone: | 8588225398 |
This study aims to learn how to improve MRIs (Magnetic Resonance Imaging) that do not require
the patient to be injected with a contrast dye. Researchers expect to learn how to better
find and describe tumors in patients with prostate cancer. Participants have a whole body
research MRI scan within 90 days of a standard-of-care imaging procedure. The research study
will collect copies of those scans to compare to the research scans as part of the study
analysis.
Patients who have additional standard-of-care scans within 12 months after their research
scan may be asked to have a second non-contrast MRI for research within 90 days of their
follow-up standard of care imaging. The whole body MRI scan will be compared to the
standard-of-care scan for prostate cancer detection and to assess patient response to
standard-of-care treatment.
the patient to be injected with a contrast dye. Researchers expect to learn how to better
find and describe tumors in patients with prostate cancer. Participants have a whole body
research MRI scan within 90 days of a standard-of-care imaging procedure. The research study
will collect copies of those scans to compare to the research scans as part of the study
analysis.
Patients who have additional standard-of-care scans within 12 months after their research
scan may be asked to have a second non-contrast MRI for research within 90 days of their
follow-up standard of care imaging. The whole body MRI scan will be compared to the
standard-of-care scan for prostate cancer detection and to assess patient response to
standard-of-care treatment.
Participants will undergo a whole body non-contrast MRI study with a whole-body protocol
incorporating routine clinical sequences as well as non-contrast research sequences. The
patient will also undergo clinically indicated standard-of-care imaging such as PET/CT, CT,
Technetium-99m bone scan or MRI with contrast as determined by the patient's oncologist. When
the standard-of-care imaging has not yet been performed upon enrollment, the research MRI
will ideally be performed on the same day as the standard-of-care exam. However, scheduling
constraints and patient time constraints may preclude scheduling both scans on the same day.
In this case, the scans will be performed within a week 90 days of each other. An experienced
radiologist will read both scans and results will be provided to the patient's oncologist for
clinical follow up.
Patients receiving additional standard-of-care imaging within 12 months after the research
MRI may be asked to return for an additional whole body MRI scan within 90 days of their
standard-of-care scan. The additional research scan will be requested of patients that have
evidence of progression during ongoing standard of care treatment and monitoring. The
additional scan would be requested of those patients to compare baseline scans to those that
are completed during standard of care imaging. This would be an additional tool to verify
disease progression or treatment response.
incorporating routine clinical sequences as well as non-contrast research sequences. The
patient will also undergo clinically indicated standard-of-care imaging such as PET/CT, CT,
Technetium-99m bone scan or MRI with contrast as determined by the patient's oncologist. When
the standard-of-care imaging has not yet been performed upon enrollment, the research MRI
will ideally be performed on the same day as the standard-of-care exam. However, scheduling
constraints and patient time constraints may preclude scheduling both scans on the same day.
In this case, the scans will be performed within a week 90 days of each other. An experienced
radiologist will read both scans and results will be provided to the patient's oncologist for
clinical follow up.
Patients receiving additional standard-of-care imaging within 12 months after the research
MRI may be asked to return for an additional whole body MRI scan within 90 days of their
standard-of-care scan. The additional research scan will be requested of patients that have
evidence of progression during ongoing standard of care treatment and monitoring. The
additional scan would be requested of those patients to compare baseline scans to those that
are completed during standard of care imaging. This would be an additional tool to verify
disease progression or treatment response.
Inclusion Criteria:
- Patients must have known or suspected genitourinary metastatic disease and have
already had or will have a CT, PET/CT, bone scan or MRI with contrast.
- Age ≥ 18 years.
- ECOG performance status 0-3.
- Capacity to give informed consent.
- Ability to lay supine for 30-60 minutes
- Ability to hear adequately without hearing aids.
Exclusion Criteria:
- Prior or current use of: cardiac pacemaker, heart valve replacement, venous umbrella
or filter, aneurysm surgery, intracranial bypass, renal or aortic clips, joint
replacements, shunts/stents, metal mesh/coil implants, metal plates/pin/screws/wires
or any other metal implants, neurostimulator, insulin pump, prosthetic devices such as
middle ear, eye, joint, or penile implants, IUD, permanent eyeliner or eyebrows, metal
fragments in eyes, skin, or body.
- Patients who were previously or are currently employed as sheet-metal workers or
welders.
- Patients may be excluded if their weight exceeds 350 lbs, the limit for the safe
operation of the MRI scanning table.
- A patient who is pregnant or trying to become pregnant will be excluded.
- Patients with any other condition that, in the opinion of the investigator, may deem
them ineligible for study participation.
We found this trial at
1
site
3855 Health Sciences Dr,
La Jolla, California 92093
La Jolla, California 92093
(858) 822-6100
Phone: 858-822-5398
UC San Diego Moores Cancer Center Established in 1978, UC San Diego Moores Cancer Center...
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