Mechanisms of Alcohol Sensitivity in AERD



Status:Recruiting
Conditions:Neurology
Therapuetic Areas:Neurology
Healthy:No
Age Range:21 - Any
Updated:5/9/2018
Start Date:May 1, 2018
End Date:September 1, 2018
Contact:BJ Ferrebee-Ghamandi, MHA
Email:Bjf8j@hscmail.mcc.virginia.edu
Phone:434-243-1558

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Trial Summary
Trial Overview
Inclusion Criteria

Mechanisms of Alcohol Sensitivity in Aspirin Exacerbated Respiratory Disease

The purpose of this study is to determine what type of reactions in the body may be
responsible for the respiratory symptoms that occur when patients with Aspirin Exacerbated
Respiratory Disease (AERD) drink alcoholic beverages. These reactions are most often seen
with red wine.

This is a prospective trial of approximately 60 subjects with AERD to explore the mechanisms
behind the physiologic reactions that occur when drinking alcoholic beverages. At various
time points patients will be asked to ingest a variety of substances found in red wine after
which blood and urine markers of the reaction will be measured.

Inclusion Criteria:

- Healthy Controls - must be 21 years or older

- Aspirin Tolerant Asthma and AERD arms must note a sensitivity to alcoholic beverages

Exclusion Criteria:

- Enzymopathies

- Mastocytosis

- Alcoholism

- Prior severe respiratory reaction to alcohol consumption

- Current pregnancy

- Monoamine Oxidase Inhibitor (MAOI) use

- Age under 21

- Use of leukotriene modifier 1 week before study intervention

- Having undergone and maintained aspirin desensitization
We found this trial at
1
site
University of Virginia
Charlottesville, Virginia 22903
(434) 924-0311
Phone: 434-243-1558
University of Virginia The University of Virginia is distinctive among institutions of higher education. Founded...
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Charlottesville, VA
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