Controlled Attenuation Parameter (CAP) in Liver Allografts
| Status: | Enrolling by invitation |
|---|---|
| Conditions: | Gastrointestinal, Gastrointestinal |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 3/28/2019 |
| Start Date: | September 7, 2016 |
| End Date: | December 2019 |
Usefulness of Controlled Attenuation Parameter (CAP) for the Assessment of Liver Steatosis in Liver Donors
The primary aim is to determine the accuracy of CAP in the quantification of liver steatosis
using liver biopsies as reference. Secondarily, investigators will correlate transient
elastography (TE) and CAP results, analyze possible associations between CAP/TE and
post-liver transplant (LT) clinical outcomes, and evaluate the change in CAP after LT. The
study aims to include as many donors as needed to achieve 100 transplanted liver allografts.
using liver biopsies as reference. Secondarily, investigators will correlate transient
elastography (TE) and CAP results, analyze possible associations between CAP/TE and
post-liver transplant (LT) clinical outcomes, and evaluate the change in CAP after LT. The
study aims to include as many donors as needed to achieve 100 transplanted liver allografts.
Inclusion criteria - Liver Recipient
- Men and women, Age 18-years old to 80-years old inclusive
Inclusion criteria - Liver Donor
- Valid TE with Fibroscan 402/530, defined as:
- At least 10 valid measurements
- IQR/Median stiffness value <30% (only in cases with >7.1 kPa)
Exclusion criteria - Liver Recipient
- Patient did not undergo liver transplantation
Exclusion criteria - Liver Donor
- Donation after circulatory death (DCD)
- No liver biopsy obtained during organ procurement process
We found this trial at
3
sites
Stanford University Stanford University, located between San Francisco and San Jose in the heart of...
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529 West Markham Street
Little Rock, Arkansas 72205
Little Rock, Arkansas 72205
(501) 686-7000
University of Arkansas for Medical Sciences The University of Arkansas for Medical Sciences (UAMS) in...
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