Insulin Resistance and Insulin Secretion
| Status: | Withdrawn |
|---|---|
| Conditions: | Endocrine, Diabetes, Diabetes |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 10 - 20 |
| Updated: | 4/17/2018 |
Phenotypic Assessment of Insulin Resistance and Insulin Secretory Capacity
This is a pilot study to examine the prevalence of metabolic risk factors (impaired insulin
release and impaired insulin sensitivity) for type 2 diabetes mellitus in children and adults
from a population that is at high risk for this disease. We hypothesize that at least one of
these pre-diabetic traits will be evident in a large proportion of relatives of known type 2
diabetic children as compared to a control group of subjects without a family history of type
2 diabetes. By isolating these traits, it will be possible to determine the relative
contributions of genes and environment to each trait and to identify those at risk for
subsequent development of type 2 diabetes by virtue of having one trait. Ultimately, those
individuals at risk, especially those with impaired insulin release, would hopefully benefit
from intervention to prevent the weight gain that will 'unmask' their underlying pancreatic
dysfunction and thus prevent or retard the development of type 2 diabetes.
release and impaired insulin sensitivity) for type 2 diabetes mellitus in children and adults
from a population that is at high risk for this disease. We hypothesize that at least one of
these pre-diabetic traits will be evident in a large proportion of relatives of known type 2
diabetic children as compared to a control group of subjects without a family history of type
2 diabetes. By isolating these traits, it will be possible to determine the relative
contributions of genes and environment to each trait and to identify those at risk for
subsequent development of type 2 diabetes by virtue of having one trait. Ultimately, those
individuals at risk, especially those with impaired insulin release, would hopefully benefit
from intervention to prevent the weight gain that will 'unmask' their underlying pancreatic
dysfunction and thus prevent or retard the development of type 2 diabetes.
Ascertainment criteria for probands:
- age 10-20 years and
- obesity (BMI >85% for sex and age)
- diabetic criteria as described above or family history (first or second degree
relative) with type 2 diabetes
We found this trial at
2
sites
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161 Fort Washington Avenue
New York, New York 10032
New York, New York 10032
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