Study of Fibrinogen Metabolism During Severe Trauma and Burns
| Status: | Completed |
|---|---|
| Conditions: | Hospital |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 11/18/2012 |
| Start Date: | February 2005 |
| End Date: | December 2013 |
| Contact: | Wenjun Z Martini, PhD |
| Email: | wenjun.martini@amedd.army.mil |
| Phone: | 210-916-4573 |
Alteration in Fibrinogen Metabolism in Patients With Severe Burns and Traumatic Injuries
To study the fibrinogen metabolic changes in relation to coagulation disorder in patients
with severe burns and trauma injuries. As a result of the burn or trauma injury breakdown of
fibrinogen is accelerated.
In this protocol, we will investigate fibrinogen metabolism in burn and trauma patients,
using an 8h infusion of stable isotopes labeled amino acids (1-13C-phenylalanine,
2H5-phenylalanine, and 2H3-ketoisocaporate). The increase of the labeled amino acids
incorporating into fibrinogen during the infusion and the decay of labeled fibrinogen after
stopping the isotopes infusion (as measured by GC-MS) will be used to calculate fibrinogen
synthesis and degradation. Stable isotopes are non-radioactive.
Inclusion Criteria:
- 20% total body surface area burn or more
- severe trauma with injury severity score greater than 10
- between ages of 18 and 65 years
Exclusion Criteria:
- history of blood clotting disorder
- history of liver disease such as cirrhosis or hepatitis
- pregnant or nursing
- allergic to iodine, shellfish or dye used in X-Rays
- taking long term medications for blood clotting usch as Coumadin or Plavix
- prisoners
- receiving total parenteral nutrition
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