Folate Supplementation in Schizophrenia

This study is a three-month, placebo-controlled trial of folate 2mg/d in 50 schizophrenia
patients who score at least a 3 (moderate or greater severity) on at least one of the SANS
global assessment subscales, with the exception of the attention global assessment subscale.
The specific aims of this study are:

- To examine factors potentially contributing to differences in blood folate, homocysteine
or B12 levels between patients at baseline, including dietary intake and cigarette
smoking.

- To test the hypothesis that low folate is associated with negative symptoms by examining
correlations between red blood cell folate concentrations and clinical ratings of
negative symptoms and by comparing folate concentrations in deficit syndrome versus
non-deficit syndrome patients. We will also control for dietary intake cigarettes
smoking, gender, and age.

- To examine the efficacy of folate supplementation for reducing negative symptoms

Inclusion Criteria:

1. Schizophrenia, any subtype

2. Ages 18-68

3. Male or female

4. A score at least a 3 (moderate or greater severity) on at least one of the SANS global
assessment subscales, with the exception of the attention global assessment subscale

5. Stable antipsychotic dose for > 6 weeks

6. Capable of providing informed consent

Exclusion Criteria:

1. Unstable medical illness

2. Substance abuse

3. Megaloblastic anemia

4. Non-english speaking