Vascular Risk After Kidney Transplantation
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Other Indications, Peripheral Vascular Disease, Renal Impairment / Chronic Kidney Disease, Endocrine, Gastrointestinal |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Endocrinology, Gastroenterology, Nephrology / Urology, Other |
| Healthy: | No |
| Age Range: | 19 - Any |
| Updated: | 4/17/2018 |
| Start Date: | April 2006 |
| End Date: | April 2019 |
Hypothesis: Nontraditional risk factors, such as inflammation, vitamin D deficiency, elevated
PTH, insulin resistance, homocysteine, or uric acid, contribute to cardiovascular disease
progression after kidney transplant.
The purpose of this study is to evaluate which traditional and nontraditional cardiovascular
disease risk factors best predict progression of cardiovascular disease (CVD) using carotid
intima media thickness performed by ultrasound, in kidney transplant patients.
PTH, insulin resistance, homocysteine, or uric acid, contribute to cardiovascular disease
progression after kidney transplant.
The purpose of this study is to evaluate which traditional and nontraditional cardiovascular
disease risk factors best predict progression of cardiovascular disease (CVD) using carotid
intima media thickness performed by ultrasound, in kidney transplant patients.
Cardiovascular disease remains the greatest cause of mortality after kidney transplant.
Traditional risk factors, such as hypertension, diabetes, hyperlipidemia and smoking,
contribute to vascular disease after transplant, but nontraditional risk factors may play a
bigger role in vascular disease progression in this setting. This observational study will
evaluate nontraditional risk factors for their contributions to vascular disease progression
as determined by carotid intima media thickness and history of vascular disease events over
time. The study requires annual checks of blood, urine, history, and carotid ultrasound for
carotid intima media thickness
Traditional risk factors, such as hypertension, diabetes, hyperlipidemia and smoking,
contribute to vascular disease after transplant, but nontraditional risk factors may play a
bigger role in vascular disease progression in this setting. This observational study will
evaluate nontraditional risk factors for their contributions to vascular disease progression
as determined by carotid intima media thickness and history of vascular disease events over
time. The study requires annual checks of blood, urine, history, and carotid ultrasound for
carotid intima media thickness
Inclusion Criteria:
- Kidney transplant more than 6 months ago
- 19 years or older
Exclusion Criteria:
- Estimated GFR <30
- Previous small bowel, or lung transplant
- Pancreas transplant less than 6 months ago
- Cancer or any condition that would change weight dramatically in the near future such
as malabsorption.
- Willing to return for testing annually for 3 years
- Women who are pregnant
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