Placebo-Controlled Study of Perifosine + Single Agent Chemotherapy for Metastatic Cancer Patients

This is an exploratory phase 2, randomized placebo-controlled trial with stratification for
disease and chemotherapy type. If there is any evidence of improved time to progression in
any tumor type with any of the drugs to be evaluated, the initial study or component(s) of
the study will be expanded to increase the certainty that this is an effect of perifosine. If
there is compelling evidence of benefit from this study, a phase 3 trial will be conducted to
obtain proof of principle.

Primary Study Objectives:

To determine the time to tumor progression when receiving single agent chemotherapy
(capecitabine) in combination with perifosine in comparison to patients receiving single
agent chemotherapy (capecitabine) alone (i.e., with placebo).

Secondary Study Objectives:

- To determine the toxicity of single agent chemotherapy in combination with perifosine.

- To compare the time to progression of chemotherapy in combination with placebo to
historical experience.

- Overall survival will also be evaluated.

Inclusion Criteria:

1. In the opinion of the treating physician, treatment with one of the following regimens
should represent an appropriate treatment for the patient.

- Capecitabine 825 mg/m2 BID days 1 - 14 q 3 weeks

2. Patients should have a histologically or cytologically confirmed diagnosis of
colorectal cancer.

3. Patients must have received at least one but no more than two prior chemotherapy
regimen(s) for the treatment of metastatic or recurrent disease.

4. ECOG performance status 0 or 1.

- Leukocytes >= 4,000/μL

- absolute neutrophil count >= 1,500/ μL

- platelets >= 100,000/ μL

- HCT > 28% (with or without growth factor support)

- Creatinine <= 2.5 mg/dl

- total bilirubin < 1.5 x upper limit of normal

- transaminase < 2.5 x upper limit of normal

5. Patients must have recovered from acute toxicity—excluding alopecia—related to prior
therapy, including surgery or radiotherapy.

6. Patients with brain metastases may be admitted, provided the disease has been treated
and been stable for 2 months.

7. Patients must have ability to understand and the willingness to sign a written
informed consent document.

Exclusion Criteria:

1. Patients receiving any other investigational agents or devices.

2. History of allergic reactions attributed to compounds of similar chemical or biologic
composition to perifosine (miltefosine or edelfosine).

3. Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, psychiatric illness, or social situations that would limit compliance with
study requirements.

4. HIV-positive patients receiving combination anti-retroviral therapy are excluded from
the study due to potential pharmacokinetic interactions with perifosine.

5. Patients with a history of unstable or newly diagnosed angina pectoris, recent
myocardial infarction (within 6 months of enrollment), or New York Heart Assoc. class
II - IV congestive heart failure.

6. Female patients who are pregnant or lactating are ineligible.