Predicting Insulin Resistance in American Indian Youth
| Status: | Completed |
|---|---|
| Conditions: | Psychiatric, Endocrine |
| Therapuetic Areas: | Endocrinology, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 5 - 18 |
| Updated: | 4/17/2018 |
| Start Date: | December 2005 |
| End Date: | March 29, 2018 |
The purpose of this study is to identify risks that may contribute to increased insulin
resistance which may help explain some of the increased incidence of type 2 diabetes in
American Indian Youth, at the Rosebud reservation ages 5 to 18 years old. If specific
positive indicators of insulin resistance are present, individuals are recruited back in one
year for repeat of all measures.
resistance which may help explain some of the increased incidence of type 2 diabetes in
American Indian Youth, at the Rosebud reservation ages 5 to 18 years old. If specific
positive indicators of insulin resistance are present, individuals are recruited back in one
year for repeat of all measures.
Type 2 diabetes is rapidly becoming more prevalent in the United States but especially among
minority populations at a younger age. Identification of risk factors, including traditional
risk factors such as increased BMI, lack of exercise, increased glucose in the diet, higher
blood pressure and lipids, along with other factors such as chronic stress, use of alcohol or
other drugs has not previously been done with minority youth. If risk factors can be
identified, more strategies for prevention of diabetes can be developed that specifically
target this population. This study will enroll 300 Native American Youth over a 4 year period
and perform body measurements including height, weight, waist circumference, blood pressure
and lab values including a 2hour glucose tolerance test, fasting lipids, and a urine albumin
creatinine ratio test. In addition, subjects will be asked to identify behavior and feelings
of stress in everyday lives. Subjects who are determined to be at increased risk of
developing diabetes will be asked to repeat the tests in one year. The results will be
reported to the tribal council to help determine prevention strategies.
minority populations at a younger age. Identification of risk factors, including traditional
risk factors such as increased BMI, lack of exercise, increased glucose in the diet, higher
blood pressure and lipids, along with other factors such as chronic stress, use of alcohol or
other drugs has not previously been done with minority youth. If risk factors can be
identified, more strategies for prevention of diabetes can be developed that specifically
target this population. This study will enroll 300 Native American Youth over a 4 year period
and perform body measurements including height, weight, waist circumference, blood pressure
and lab values including a 2hour glucose tolerance test, fasting lipids, and a urine albumin
creatinine ratio test. In addition, subjects will be asked to identify behavior and feelings
of stress in everyday lives. Subjects who are determined to be at increased risk of
developing diabetes will be asked to repeat the tests in one year. The results will be
reported to the tribal council to help determine prevention strategies.
Inclusion Criteria:
- Native American youth between ages of 5 and 18 who are eligible for health care at
Rosebud Sioux Reservation (Rosebud, SD) and willing to be measured and participate in
a 2 hour glucose tolerance test and who have parental consent.
Exclusion Criteria:
- Those who have diabetes previously identified or those with chronic steroid use, or
identified conditions that affect weight balance such as cancer.
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