Iron Overload in Stem Cell Transplant Recipients
| Status: | Completed |
|---|---|
| Conditions: | Hematology |
| Therapuetic Areas: | Hematology |
| Healthy: | No |
| Age Range: | 5 - Any |
| Updated: | 4/17/2018 |
| Start Date: | February 2007 |
| End Date: | October 2010 |
Impact of Iron Overload in Pediatric Patients Undergoing Stem Cell Transplantation
The goal of this study is to examine the impact of iron overload in patients undergoing a
bone marrow transplant. We believe that the iron status in these patients is associated with
complications for transplant survivors. We will examine the iron status in these patients by
MRI and by screening for mutations in genes known to cause iron overload. We will also
determine the levels of hepcidin (a hormone produced in the liver that appears to regulate
iron homeostasis) from blood and urine.
bone marrow transplant. We believe that the iron status in these patients is associated with
complications for transplant survivors. We will examine the iron status in these patients by
MRI and by screening for mutations in genes known to cause iron overload. We will also
determine the levels of hepcidin (a hormone produced in the liver that appears to regulate
iron homeostasis) from blood and urine.
1. Undergoing allogeneic HSCT for malignant or non-malignant conditions
2. Age greater than or equal to 5 years
3. Able to undergo MRI without a need for general anesthesia
4. No metal implants
5. Signed informed consent (by parent if patient is less than 18 years old, or by
patient, if he or she is greater than 18 years old).
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