Comparative Study to Evaluate ISV-305 Compared to Vehicle in Blepharitis Subjects

Inclusion Criteria:

- Are at least 1 years of age and have a clinical diagnosis of active, symptomatic
blepharitis

- Signature of the subject or parent(s) or legally authorized representative on the
Informed Consent Form, and when appropriate the minor's assent in accordance with
local regulations

- Are willing and able to follow all instructions and attend all study visits (this
applies to parent or caregiver for subjects too young to self-apply investigational
product)

- Are willing to avoid disallowed medication for the duration of the study

- If female is of childbearing potential, agree to and submit a urine sample for
pregnancy testing (prior to enrollment and at the end of the study) and use effective
contraception for the duration of the study

- Male subjects whose female partners are not post-menopausal must agree to one of the
following: 1) completely abstain from sexual intercourse, 2) use a barrier method
(condoms) with spermicide during sexual intercourse for the duration of the study, 3)
provide documentation for having had a vasectomy (with documented infertility)

- Additional inclusion criteria also apply

Exclusion Criteria:

- Have known sensitivity or poor tolerance to any component of the study drugs

- Have had eyelid surgery in the study eye within twelve (12) months prior to Visit 1 or
plan to have eyelid surgery during the study

- Have an acute ocular infection (bacterial, viral or fungal) or active ocular
inflammation other than blepharitis in the study eye

- Have used topical medications on the eyelids or topical ophthalmic corticosteroid
medications or systemic use of a corticosteroid mediation within 14 days prior to
dosing and/or plan to use them throughout the duration of the study

- Be currently pregnant, nursing, or planning a pregnancy; or be a woman who has a
positive urine pregnancy test

- Have prior (within 30 days prior to dosing) or anticipated concurrent use of an
investigational drug or device

- Have a condition or a situation which, in the investigator's opinion, may put the
subject at increased risk, confound study data, or interfere significantly with the
subject's study participation

- Additional exclusion criteria also apply