Molecular Mechanisms of Antipsychotic-induced Insulin Resistance

We will include persons that meet the following criteria:

1. 21-45 years old

2. BMI 18.5-24.9kg/m2

3. No history of drug or alcohol dependence or abuse

4. No current or past history of psychiatric or neurologic disease

5. minimal exercise routine prior or during study (light walking allowed)

6. Normal liver function tests

7. minimal alcohol intake (<1 drink per day).

The following persons will be excluded:

1. Has 1st degree relative with diabetes (I or II)

2. current or re-cent nicotine intake

3. presence of organic/physical disease that could affect glucose

4. currently taking prescription or over-the-counter medications that could affect
glucose

5. currently pregnant or lactating

6. unwilling to take acceptable birth control method

7. current or previous exposure to antipsychotics

8. history of unstable weight

9. personal or family history of cardiac arrhythmias or seizures

10. current or past history of eating disorder(s) or restricted diet

11. allergy to lidocaine or drug excipients

12. history of difficulty with intravenous line placement

13. history of fainting.