Characterization of the Analgesic Effect of CBD in Healthy, Normal Volunteers
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Chronic Pain |
| Therapuetic Areas: | Musculoskeletal |
| Healthy: | No |
| Age Range: | 21 - 50 |
| Updated: | 4/5/2019 |
| Start Date: | June 2016 |
| End Date: | December 2021 |
Characterization of the Analgesic Effects of Oral CBD in Healthy, Normal Volunteers
The purpose of this double-blind, placebo-controlled study is to determine the analgesic
effects of cannabidiol (CBD), a chemical constituent found in cannabis that does not have
intoxicating effects. The analgesic effects of CBD will be assessed using the Cold-Pressor
Test (CPT), a laboratory model of pain which has predictive validity for the clinical use of
analgesics.
effects of cannabidiol (CBD), a chemical constituent found in cannabis that does not have
intoxicating effects. The analgesic effects of CBD will be assessed using the Cold-Pressor
Test (CPT), a laboratory model of pain which has predictive validity for the clinical use of
analgesics.
This within-subject, double-blind, placebo-controlled study will assess the analgesic and
subjective effects of a range of CBD doses (0, 200, 400, or 800 mg, po). Volunteers will
participate in 4 outpatient laboratory sessions over the course of 4 weeks during which the
analgesic effects of CBD will be assessed using the Cold-Pressor Test (CPT), a laboratory
model of pain which has predictive validity for the clinical use of analgesics. The order of
CBD dose will be randomized across participants. Secondary measures will include subjective
and physiologic effects of CBD.
subjective effects of a range of CBD doses (0, 200, 400, or 800 mg, po). Volunteers will
participate in 4 outpatient laboratory sessions over the course of 4 weeks during which the
analgesic effects of CBD will be assessed using the Cold-Pressor Test (CPT), a laboratory
model of pain which has predictive validity for the clinical use of analgesics. The order of
CBD dose will be randomized across participants. Secondary measures will include subjective
and physiologic effects of CBD.
Inclusion Criteria:
- Able to perform study procedures
- Women practicing an effective form of birth control
Exclusion Criteria:
- Female subjects who are currently pregnant or breastfeeding.
- Current illicit drug use
- Presence of significant medical illness
- History of heart disease
- Request for drug treatment
- Current parole or probation
- Recent history of significant violent behavior
- Major psychiatric disorder
- Current use of any prescription or over-the-counter medication
- Current pain
- Clinically significant Raynaud's syndrome
We found this trial at
1
site
