Identification of Tongue Involvement in Late-Onset Pompe Disease

Inclusion Criteria:

- age ≥ 12 years

- confirmed diagnosis of LOPD and naïve to enzyme-replacement therapy (ERT)

- acquired/hereditary myopathy (e.g., dermatomyositis, polymyositis, inclusion body
myositis, limb-girdle muscular dystrophy, distal myopathy, myotonic muscular
dystrophy, and other myopathy)

- neuropathy (e.g., peripheral neuropathy, cranial neuropathy, autonomic neuropathy,
focal neuropathy)

Exclusion Criteria:

- current use, history within the past two years of use, or eligible but declined use of
Lumizyme® enzyme replacement therapy (applicable to LOPD group)

- history of stroke, Parkinson's disease, oculopharyngeal muscular dystrophy, head and
neck cancer or radiation treatment to head/neck, or other conditions that commonly
affect lingual strength

- inability to follow directions for study participation