ToRsemide for pOstpartum HYpertension
| Status: | Completed |
|---|---|
| Conditions: | High Blood Pressure (Hypertension), Women's Studies |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Reproductive |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/17/2018 |
| Start Date: | August 2016 |
| End Date: | September 9, 2017 |
Torsemide for the Prevention of Persistent Postpartum Hypertension in Preeclamptic Women: A Randomized, Placebo-Control Trial
Currently there is no intervention to prevent persistent postpartum hypertension in
preeclamptic women. Physiologically, the use of a pharmacokinetically predictable
loop-diuretic is a reasonable intervention to increase elimination of extra fluid accumulated
secondary to preeclampsia.The purpose of this study is to assess if Torsemide reduces the
incidence of persistent postpartum hypertension in preeclamptic women.
preeclamptic women. Physiologically, the use of a pharmacokinetically predictable
loop-diuretic is a reasonable intervention to increase elimination of extra fluid accumulated
secondary to preeclampsia.The purpose of this study is to assess if Torsemide reduces the
incidence of persistent postpartum hypertension in preeclamptic women.
Inclusion Criteria:
- Postpartum women at ≥ 18 years of age
- Antepartum/intrapartum or within 24 hours postpartum diagnosis of either:
- Preeclampsia
- Preeclampsia with severe features
- Preeclampsia superimposed to chronic hypertension
Exclusion Criteria:
- Chronic hypertension without superimposed preeclampsia
- Gestational hypertension
- Urine output < 30 cc/h at time of randomization
- Heart failure or pulmonary edema
- Hypersensitivity to Torsemide or sulfonylureas
- Hypokalemia (serum potassium < 3 mEq/L)
- Preexisting diuretic use within 24 hours prior to randomization
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