Neural Circulatory Control and SUDEP Risk.
| Status: | Recruiting |
|---|---|
| Conditions: | Neurology, Neurology, Epilepsy |
| Therapuetic Areas: | Neurology, Other |
| Healthy: | No |
| Age Range: | 18 - 50 |
| Updated: | 3/24/2019 |
| Start Date: | June 2016 |
| End Date: | May 2022 |
| Contact: | Lisa D. Block |
| Email: | CPL@mayo.edu |
| Phone: | 507 255 0492 |
Neural Circulatory and Respiratory Control in Patients With Epilepsy and the Risk of Sudden Unexpected Death.
The investigators believe epilepsy alters the way the body controls blood pressure, heart
rate and breathing, and these changes increase the risk of sudden unexpected death in
patients with epilepsy (SUDEP). SUDEP-7 is a risk scoring tool which may correlate with these
changes to the heart and blood vessels. This research study measures those differences which
may help identify new markers to help predict those patients at greatest risk in the future.
rate and breathing, and these changes increase the risk of sudden unexpected death in
patients with epilepsy (SUDEP). SUDEP-7 is a risk scoring tool which may correlate with these
changes to the heart and blood vessels. This research study measures those differences which
may help identify new markers to help predict those patients at greatest risk in the future.
The investigators overall goals are to determine whether measures of neural-circulatory
control during the interictal waking and sleep states, as well as during the ictal/peri-ictal
periods, are associated with SUDEP-7 score risk profiles in refractory epilepsy patients, and
to translate these measures into tools for risk-stratification and preventative strategies
for SUDEP.
control during the interictal waking and sleep states, as well as during the ictal/peri-ictal
periods, are associated with SUDEP-7 score risk profiles in refractory epilepsy patients, and
to translate these measures into tools for risk-stratification and preventative strategies
for SUDEP.
Inclusion Criteria:
- Adults aged 18-50
- Able to consent
Exclusion Criteria:
- History of non-epileptic spells/seizures,
- Children/adolescents under age 18 years
- Pregnancy
- Non-compliance with Epilepsy Monitoring Unit safety procedures
- Unable to consent
- History of dysautonomia
- Chronic Obstructive Pulmonary Disease (COPD)
- Asthma (active requiring therapy)
- Pulmonary hypertension
- Known Structural Heart Disease
- Heart failure
- Myocardial infarction
- Stroke
- Seizures due to traumatic injury
- Prior surgery for epilepsy
- Vasculitis
- Raynaud's
- Smoking (current or within the last 6 months)
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