Ocular Adaptation and Visual Performance for Accommodative Contact Lens

In the proposed study we plan to recruit presbyopes (people who might have a significant loss
of their ability to accommodate their crystalline lens in the eye) to wear a test lens and
perform typical clinical tests of visual acuity with different luminance levels and viewing
distances/angles. These are similar to the typical examinations conducted for regular contact
lens wearers. Results of this testing will be used to evaluate the efficacy of test lenses
and to provide additional information for revision of test lenses. If shown to provide
adequate eye comfort and intended vision correction, this lens design has the potential of
allowing tens of millions of presbyopes to adapt to contact lenses and significantly improve
their vision and well-being.

Inclusion Criteria:

- Be between 40 and 65 years of age.

- Have normal/corrected-to-normal monocular acuity of better than 20/25 for both eyes.

- Have pupil diameter in regular lighting ≥ 2.5 mm.

- Willing and able to wear multifocal contact lenses in both eyes.

- Have a current optical prescription (obtained less than 2 years ago).

- Have spherical equivalent correction equal to or higher than -1.00 Diopter and equal
to or less than +0.50 Diopter.

- Have cylindrical correction equal to less than 0.50 Diopter.

Exclusion Criteria:

- Have no prismatic correction.

- Without any eye infection, inflammation, disease, or abnormality that contraindicates
contact lens wear within the past 6 months.

- No clinically significant ocular pathology (e.g., cataract, keratoconus, dry eye,
diabetic retinopathy, or age-related macular degeneration)

- Have no photosensitive disorders, including migraine and seizure.

- Have no binocular dysfunction, including amblyopia, strabismus, and other binocular
diseases.