Metformin Hydrochloride and Ritonavir in Treating Patients With Relapsed or Refractory Multiple Myeloma or Chronic Lymphocytic Leukemia

PRIMARY OBJECTIVES:

I. To assess the safety, tolerability and feasibility of administering metformin
hydrochloride (metformin)/ritonavir combination therapy in patients with relapsed/refractory
multiple myeloma or relapsed/refractory chronic lymphocytic leukemia.

SECONDARY OBJECTIVES:

I. To characterize the clinical activity of this two-drug combination by assessing disease
response, response duration, and (in relapsed/refractory multiple myeloma [RRMM]) clinical
benefit response.

II. To assess the progression-free survival, overall survival and compliance of all patients
who start the two-drug combination.

III. To evaluate potential changes in health-related quality of life, as assessed by the
Functional Assessment of Cancer Therapy for Multiple Myeloma (FACT-MM) and Leukemia
(FACT-Leu).

TERTIARY OBJECTIVES:

I. To describe the plasma pharmacokinetics of metformin and ritonavir when given in
combination.

II. In relapsed/refractory chronic lymphocytic leukemia (RRCLL), to describe changes in pAKT,
pAMPK, and MCL-1, in circulating lymphocytes in response to treatment.

OUTLINE: This is a dose escalation study.

SINGLE AGENT STAGE: Patients receive metformin hydrochloride orally (PO) twice daily (BID) on
days 1-7 in the absence of disease progression or unacceptable toxicity.

COMBINATION REGIMEN STAGE: Patients receive metformin hydrochloride PO BID and ritonavir PO
BID on days 1-7. Courses repeat every 28 days in the absence of disease progression or
unacceptable toxicity.

After completion of study treatment, patients are followed up at 30 days and then every 28
days.

Inclusion Criteria:

- All subjects must have the ability to understand and the willingness to sign a written
informed consent

- Life expectancy of > 3 months

- Eastern Cooperative Oncology Group (ECOG) performance status of 0-2

FOR PATIENTS WITH MULTIPLE MYELOMA (MM):

- Diagnosis of multiple myeloma

- Patients with MM must have measurable disease, defined as one or more of the
following:

- Serum M-protein >= 0.5 g/dL

- Urine M-protein >= 200 mg/24 hr

- Serum immunoglobulin free light chain (FLC) >= 100 mg/L (10 mg/dL) and abnormal
serum immunoglobulin kappa to lambda FLC ratio

- IgA patients must have serum quantitative immunoglobulin >= 750 mg/dL

- Patients with oligosecretory or non-secretory disease must have a documented
abnormal free light chain ratio (normal value 0.26 to 1.65) or a value
beyond the laboratory calculation range

- Disease must be refractory or relapsed after >= 3 prior regimens (induction therapy
and stem cell transplant +/- maintenance will be considered as one regimen)

FOR PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA (CLL):

- Diagnosis of CLL without the following: Richter's transformation, prolymphocytic
leukemia (PLL), small lymphocytic lymphoma (SLL)

- Measurable disease, defined as one or more of the following:

- Lymphocytosis >= 5000 in peripheral blood

- Measurable lymph nodes > 1.5 cm on palpation and/or computed tomography (CT) scan

- Organomegaly by physical exam and/or CT scan

- Active disease per International Workshop on Chronic Lymphocytic (IWCLL) 2008
criteria, as defined as one of the following:

- Evidence of progressive marrow failure as manifested by the development of, or
worsening of, anemia and/or thrombocytopenia

- Massive (i.e., at least 6 cm below the left costal margin) or progressive or
symptomatic splenomegaly

- Massive nodes (i.e., at least 10 cm in longest diameter) or progressive or
symptomatic lymphadenopathy

- Progressive lymphocytosis with an increase of more than 50 percent over a
two-month period or lymphocyte doubling time (LDT) of less than six months; LDT
can be obtained by linear regression extrapolation of absolute lymphocyte counts
obtained at intervals of two weeks over an observation period of two to three
months; in patients with initial blood lymphocyte counts of less than 30 x 10^9/L
(30,000/L), LDT should not be used as a single parameter to define a treatment
indication; in addition, factors contributing to lymphocytosis or lymphadenopathy
other than CLL (e.g., infection) should be excluded

- Autoimmune anemia and/or thrombocytopenia that is poorly responsive to
corticosteroids or other standard therapy

- Constitutional symptoms, defined as any one or more of the following
disease-related symptoms or signs:

- Unintentional weight loss of 10 percent or more within the previous six
months

- Significant fatigue (i.e., ECOG performance scale [PS] 2 or worse; inability
to work or perform usual activities)

- Fevers higher than 100.5 degrees Fahrenheit (F) or 38.0 degrees Celsius (C)
for two or more weeks without other evidence of infection

- Night sweats for more than one month without evidence of infection

- Received at least 2 prior therapies (regimens) for CLL

- In the opinion of the investigator do not require rapid cytoreduction due to bulky
disease (e.g. painful lymphadenopathy or organomegaly, or impending end-organ
dysfunction

- Absolute neutrophil count (ANC) >= 1,000/mm^3

- Platelets >= 50,000/mm^3

- Aspartate aminotransferase (AST) =< 3 x upper limit of normal (ULN)

- Alanine aminotransferase (ALT) =< 3 x ULN

- Total bilirubin =< 1.5 x ULN; unless presence of Gilbert's syndrome, liver involvement
by CLL or MM, or stable chronic liver disease per investigator's assessment

- Creatinine clearance of >= 45 mL/min per 24 hour urine collection or the
Cockcroft-Gault formula

- Woman of childbearing potential (WOCBP): negative urine or serum pregnancy test; if
the urine test is positive or cannot be confirmed as negative, a serum pregnancy test
will be required

- Corrected QT interval (QTc) =< 480 msec per Fridericia's formula AND PR interval =<
200 msec (using 12-lead electrocardiography [EKG])

- Agreement by woman of childbearing potential and sexually active males to use an
effective method of contraception (hormonal or barrier method of birth control or
abstinence) prior to study entry and for three months following duration of study
participation

- A woman of childbearing potential is defined as a sexually mature woman who:

- Has not undergone a hysterectomy or bilateral oophorectomy; or

- Has not been naturally postmenopausal for at least 24 consecutive months

FOR PATIENTS WITH MM OR CLL:

- At least 2 weeks from prior therapy to time of start of treatment; prior therapy includes
steroids (except for =< 10 mg daily prednisone or equivalent which is permitted during the
study)

Exclusion Criteria:

- Current or planned use of other investigational agents, or concurrent biological,
chemotherapy, or radiation therapy during the study treatment period

- Use of a protease inhibitor for any indication within three months prior to start of
study treatment

- Current or planned use of prohibited meds

- Liver disease, except Gilbert's syndrome, liver involvement by CLL or MM, or stable
chronic liver disease per investigator's assessment

- Current pancreatitis

- History of allergic reactions or hypersensitivity attributed to compounds of similar
chemical or biologic composition to metformin, ritonavir or any of their ingredients

- Non-hematologic malignancy within the past 3 years aside from the following
exceptions:

- Adequately treated basal cell or squamous cell skin cancer

- Carcinoma in situ of the cervix

- Prostate cancer < Gleason grade 6 with a stable prostate-specific antigen test
(PSA)

- Successfully treated in situ carcinoma of the breast

- Clinically significant cardiac disease, including:

- >= Grade 2 myocardial infarction within 6 months prior to day 1 of protocol
therapy

- Unstable or uncontrolled disease condition relating to or affecting cardiac
function (e.g. unstable angina, congestive heart failure, New York Heart
Association Class III-IV) within 6 months prior to day 1 of protocol therapy

- >= Grade 2 uncontrolled cardiac arrhythmia

- Clinically significant medical disease or condition that, in the investigator's
opinion, may interfere with protocol adherence or the patient's ability to give
informed consent

- Women who are currently or planning to breastfeed during protocol treatment

- Any other condition that would, in the investigator's judgment, contraindicate the
patient's participation in the clinical study due to safety concerns or compliance
with clinical study procedures, e.g., infection/inflammation, intestinal obstruction,
unable to swallow medication, social/ psychological issues, uncontrolled intercurrent
illness etc.

- Prospective participants who, in the opinion of the investigator, may not be able to
comply with all study procedures (including compliance issues related to
feasibility/logistics)