Pomegranate Supplementation and Well-Being Among Medical Students and Residents
| Status: | Enrolling by invitation |
|---|---|
| Healthy: | No |
| Age Range: | 21 - 40 |
| Updated: | 4/17/2018 |
| Start Date: | February 28, 2017 |
| End Date: | February 1, 2021 |
Medical students and residents have high rates of mental distress and burnout related to the
intellectual and time demands of their training. Research shows that physiological stress on
the body can be a result of fatigue and high stress work, and is associated with experiences
related to mental distress. Pomegranate is a fruit that is known to contain a variety of
antioxidant substances that can reduce physiological stress. This study will look at the
potential for pomegranate supplementation to reduce physiological stress and improve
well-being in medical students and residents.
intellectual and time demands of their training. Research shows that physiological stress on
the body can be a result of fatigue and high stress work, and is associated with experiences
related to mental distress. Pomegranate is a fruit that is known to contain a variety of
antioxidant substances that can reduce physiological stress. This study will look at the
potential for pomegranate supplementation to reduce physiological stress and improve
well-being in medical students and residents.
This is a pilot study to investigate the feasibility of conducting a randomized trial of
pomegranate supplementation in medical students and residents, and to see whether there is
evidence of an effect on reported emotional and physical well-being.
Phase 1 will be a pilot with 10 participants in which all will receive the pomegranate
supplement for 28 days. In phase 2, we will randomize 40 participants (1:1) to receive either
the pomegranate supplement or a placebo.
For both phases, we will measure self reported emotional and physical well-being using
several questionnaires, and we will conduct laboratory testing for measures of oxidative
stress and inflammatory biomarkers in blood, and for a metabolite of pomegranate in urine.
pomegranate supplementation in medical students and residents, and to see whether there is
evidence of an effect on reported emotional and physical well-being.
Phase 1 will be a pilot with 10 participants in which all will receive the pomegranate
supplement for 28 days. In phase 2, we will randomize 40 participants (1:1) to receive either
the pomegranate supplement or a placebo.
For both phases, we will measure self reported emotional and physical well-being using
several questionnaires, and we will conduct laboratory testing for measures of oxidative
stress and inflammatory biomarkers in blood, and for a metabolite of pomegranate in urine.
Inclusion Criteria:
- First or second year medical student or first or second year resident listed at the
University of Mississippi Medical Center
Exclusion Criteria:
- Pregnant or planning to become pregnant during the study period.
- Breast feeding.
- Unable to speak, understand, and read English.
- Taking chronic medications other than contraception
- Taking supplements (including over-the-counter multivitamins)
- Allergy to pomegranate or gelatin (gel-caps)
- Baseline scores on the DASS-21 that indicate a level of depressive or anxiety symptoms
that is "severe" or "extremely severe." This would be a depression score greater than
10, or an anxiety score greater than 7.
We found this trial at
1
site
University of Mississippi Medical Center The University of Mississippi Medical Center, located in Jackson, is...
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