Evaluation of a Commercial Program on Weight Loss and Health Outcomes 2

Inclusion Criteria:

- Male or female ages 18-75 years. Set "soft quotas" on the number of male and female
participants. The desire is to have an 80% female/20% male split.

- Willing to enroll in the Weight Watchers Program

- With or without previous Weight Watchers experience Set maximum quota on the number of
participants with previous Weight Watchers experience at 65%.

- Self-reported height/weight resulting in a Body Mass Index (BMI) of 25 to 43 (will
re-screen at facility).

- Self report that he/she feels the need to lose weight.

- Willing to discontinue any current over-the-counter (OTC) supplements not
recommended/prescribed by physician, with the exception of multivitamins or other
vitamin supplement.

- Willing to follow recommendations required by study protocol.

- Willing to include demographic information (e.g., ethnicity, income and education).

- Use of a personal iPhone on a daily basis

1. iPhone must have iOS 8.0 or later

2. Must have at least 600 MB of available storage to accommodate the size of the app

- The willingness and ability to navigate and use applications on their iPhone on a
daily basis (minimum training will be provided)

- Reliable home Wi-Fi access

- Ability to commit to attending up to 27 study visits in approximately 26 weeks:

1. Ability to commit (to best of their ability) to attending weekly meetings, 30-60
minutes in duration, on the same day and at the same time each week for 24
consecutive weeks.

2. Ability to commit to up to 3 additional study visits at Weeks 0, 12 and 24, with
each visit being 60-90 minutes in duration to complete assessments (height,
weight, questionnaires, physical measures).

Exclusion Criteria:

- Currently, or within the last 6 months, trying to lose weight by following guidelines
(e.g., self-initiated programs such as 5-2, or Atkins) or a structured weight-loss
program (e.g., at a medical center, university, commercial programs)

- A member of Weight Watchers within the past 12 months.

- Involved in any other related research studies and self-report agreeing to not enroll
in other studies that may affect weight or health outcomes over the next 12 months.

- Pregnant or nursing, or planning on becoming pregnant over the next 9 months.

- Weight loss of ≥ 5 kg in the previous 6 months.

- History of clinically diagnosed eating disorder.

- Reported health problems that make weight loss or unsupervised exercise unsafe or
unreasonable (e.g., orthopedic limitations, heart problems)

- Untreated thyroid disease or any changes (type or dose) in thyroid medication in last
6 months.

- Taking any prescription medication with known effects on appetite or weight (e.g.,
oral steroids, weight loss medications such as Qysmia, Contrave, etc.) with the
exception of subjects on a stable dose of Selective Serotonin Reuptake Inhibitors
(SSRIs) for 6 months

- Diuretic use for hypertension over 1.5mg per day

- Chronic/inflammatory gastrointestinal disorders (irritable bowel syndrome acceptable).

- History of heart problems (e.g., angina, bypass surgery, myocardial infarction, etc.)
within previous 6 months.

- Resting systolic blood pressure >160 mmHg or resting diastolic blood pressure >100
mmHg

- Diagnosis of type 1 or type 2 diabetes.

- Previous surgical procedure for weight loss.

- Major surgery within the previous 6 months.

- Presence of implanted cardiac defibrillator or pacemaker.

- History of cancer within past 5 years or current treatment for cancer (completely
resected basal or squamous cell carcinoma acceptable if treatment completed more than
6 months prior to enrollment).

- Hospitalization for psychiatric problems during the past 12 months.

- Consuming more than 14 alcoholic drinks per week or not more than 3 drinks per day.

- Planning to relocate in the next 9 months.