Design and Validation of a New Assessment Tool for Lichen Planopilaris

Inclusion Criteria:

1. Male or female subjects in general good health between the ages of 18 and 80 years old

2. Clinical and histologic diagnosis of lichen planopilaris

3. Subject is able to understand and sign informed consent

4. Subject is able to complete the study and comply with study procedures

5. Subject has no known allergy to non-toxic ink

6. Subjects should be managed by an Massachusetts General Hospital dermatologist for
their lichen planopilaris for the duration of the study

Exclusion Criteria:

Eligible subjects will be excluded from participation if they meet any of the following
criteria:

1. Presence of dermatoses that might interfere with LPP diagnosis and/or evaluation such
as seborrheic dermatitis or psoriasis

2. Other selected concomitant causes of hair loss, including discoid lupus erythematosus,
central centrifugal cicatricial alopecia (CCCA), telogen effluvium

3. Abnormal TSH laboratory value >1 standard deviation above normal within last year

4. Any significant medical condition that may prevent the patient from participating in
the study according to the investigator's assessment

5. Any known allergy to non-toxic ink Related to Biopsy

6. History of poor wound healing or blood-clotting abnormality

7. History of keloid formation or hypertrophic scarring

8. Regular intake of high doses of aspirin or anti-coagulant medications

9. Hypersensitivity to local anesthetics

10. History of poorly controlled diabetes mellitus

11. Pregnant, nursing or planning a pregnancy