Communicating Health Information and Improving Coordination With Primary Care

What is the CHIIP Study? The CHIIP Study is for Long-Term Follow-Up (LTFU) Study participants
who are more likely to experience heart problems because of their cancer treatment. We want
to figure out how common high blood pressure, high blood cholesterol, and high blood sugar
are among LTFU Study participants.

What will be asked of participants?

LTFU Study participants who choose to enroll in this study will be asked to:

- Answer one or two short questionnaires about their medical history, current health,
mood, lifestyle, and healthcare access.

- Schedule a one-time visit for an examiner to come to their home (or another location
chosen by the participant) to measure blood pressure, height, weight, waist
circumference, and to draw blood to test their cholesterol and blood sugar.

- If all the test results are normal, the participant will be done with the study. If the
participant has a higher than normal test result, they will remain in the study and be
randomly assigned to one of two groups to learn how to improve health. A year later,
participants in both groups will be asked to repeat the tests mentioned above.

What's in it for participants? Participants will have some basic health measurements done for
free, including height, weight, blood pressure, and blood levels of cholesterol and sugar.

The participant and their primary care provider will receive a copy of all these test results
free of cost. We hope the information we gather will provide future benefits for people who
were treated for cancer as children.

Inclusion Criteria:

- CCSS participant who is age ≥18 years at time of consent

- High cardiovascular risk status based on CCSS risk prediction models for
cardiomyopathy and ischemic heart disease

- Able to read, write, and speak English

- Living in the U.S., within 50 miles of a designated EMSI center based on CCSS's
available contact information at the time of approach.

- At least one abnormal CV condition identified on home visit: blood pressure ≥130/80
mmHg or ≥130/80 if pre-existing hypertension; LDL ≥160 mg/dL; triglyceride ≥150 mg/dL
(if ≥10 hours fast) or ≥200 mg/dL (if <10 hours fast); or glucose ≥100 mg/dL if ≥8
hours fast) or ≥140 mg/dL (if <8 hours fast) or HbA1c ≥5.7% (if not known to be
diabetic), HbA1c ≥7% (if known diabetic)

- Free of known self-reported ischemic heart disease or cardiomyopathy

- Have access to a telephone, computer, or smartphone to receive a phone or web
video-based educational intervention

Exclusion Criteria:

- Individuals with known cardiomyopathy or ischemic heart disease based on prior CCSS
surveys are excluded. While not likely to be common, participants who newly report in
our study's baseline survey that they have cardiomyopathy or ischemic heart disease
can have a home visit completed but will then be done with the study regardless of
their home visit results.

- Not currently known to be pregnant; individuals known to be pregnant and otherwise
eligible for the study can be enrolled once no longer known to be pregnant.
Participants who report being pregnant AFTER randomization can remain in the study.