Use of Protamine for Heparin Reversal After Catheter Ablation of Atrial Fibrillation
| Status: | Completed |
|---|---|
| Conditions: | Atrial Fibrillation |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 10/25/2018 |
| Start Date: | March 23, 2017 |
| End Date: | April 3, 2018 |
Use of Protamine for Heparin Reversal After Catheter Ablation of Atrial Fibrillation: A Randomized Trial
The objective of this study is to evaluate the safety, efficacy and efficiency of rapid
anticoagulation reversal with protamine sulfate versus routine activated clotting time (ACT)
monitoring in patients undergoing catheter based ablation of atrial fibrillation.
anticoagulation reversal with protamine sulfate versus routine activated clotting time (ACT)
monitoring in patients undergoing catheter based ablation of atrial fibrillation.
Inclusion Criteria:
- Patient's referred for radiofrequency ablation (RFA) or cryoablation for atrial
fibrillation or atrial flutter (left atrial).
- Age ≥ 18 year
- Patients who are mentally and linguistically able to understand the aim of the trial,
comply with the trial protocol, verbally acknowledge the risks, benefits, and
alternatives in this trial.
Exclusion Criteria:
- Previous intolerance or allergy to heparin products.
- Current or prior administration of protamine products
- History of femoral access site complications including hematoma, AV fistula,
pseudoaneurysm, aneurysm.
- Known lower extremity venous thrombosis.
- Coagulopathy or blood dyscrasias.
- Active malignancy.
- Thrombocytosis (platelet count >600k/ul) or thrombocytopenia (platelet count <100k/ul)
- Planned use of vascular closure device
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