The Effects of Strawberry Supplementation on Memory and Gait Among Over-weight Older Adults

Previously, the investigators have shown that dietary berry fruit are able to reverse several
parameters of brain aging, as well as age-related motor and cognitive deficits when fed to
aged rats. They have shown that strawberry, in particular, can reduce oxidative stress and
pro-inflammatory signaling in the brain and improve both mobility and cognition. A recent
study also found that the addition of two servings of strawberry per day for 3 months could
significantly improve verbal and spatial memory among healthy older adults, particularly on
tests with high cognitive demand. These effects may reflect the direct effects of
strawberries' bioactive and neuroavailable polyphenols on brain signaling or their indirect
effects through antioxidant and anti-inflammatory pathways. However, participants in that
study were selected from a healthy aging population, which made it difficult to detect
changes in balance, mobility, and the less complex cognitive tasks. Therefore, the
investigators are proposing the current study to assess the effects of dietary strawberry on
mobility and cognition among a compromised population, obese older adults, who are at
increased risk for cardiovascular, metabolic, and neurodegenerative disease. The risk for
heart disease, diabetes, stroke, cancer and dementia increases in direct relation to
overweight and obesity measures, and research now shows that obesity is a primary cause of
mental deterioration among the middle-aged and senior populations. In this study, obese older
adults (55-75yo, BMI 30-36) will consume 24g/d freeze-dried strawberry or control powder for
3 months and complete a battery of lifestyle, mobility, and cognitive tests at 3 time points.
The investigators hypothesize that supplementing obese older adults' diet with strawberry
will improve performance on complex tasks involving mobility and cognition.

Inclusion Criteria:

- Between the ages of 55 and 75 years

- Body mass index (BMI) between 30-40

- Hemoglobin A1C level between 5.7 and 6.4%

- Height between 60 and 74 inches tall

- Adequate visual acuity or corrected visual acuity to read and perform computer tasks

- Fluency in spoken and written English

- Ability to walk independently for 20 minutes as per self-report.

- Women must be postmenopausal (absence of menstruation for a minimum of 12-months or
bilateral oophorectomy)

- Willing to abstain from recreational drug use

Exclusion Criteria:

- Vegetarian or vegan

- Cognitive impairment, memory loss, or neurologic/psychological disorder that interfere
with activities of daily living

- Muscle or mobility deficit that would interfere with walking independent for 20
minutes

- Chronic conditions associated with increased risk of falls or falls within the last
year that were not precipitated by unusual circumstances (e.g. slipping on ice, being
pushed)

- Gastrointestinal diseases, conditions, or medications influencing gastrointestinal
absorption

- Use of medications or dietary supplements known or suspected to influence study
outcomes

- Mini Mental State Exam (MMSE) score of less than 24 at screening

- Diabetes mellitus diagnosis or fasting glucose >= 126 mg/dL or taking diabetes
medication

- Liver dysfunction, history of cirrhosis, or elevated SGPT, SGOT, or total bilirubin

- Kidney disease as indicated by serum creatinine > 1.5 mg/dL at screening

- Uncontrolled blood pressure

- Cardiac or pulmonary conditions that limit ambulation or results in dyspnea with
ambulation

- Allergy to strawberry or ingredients in the placebo.

- Ethanol use above 2 servings/day of beer (12-ounces), wine (5 ounces) or liquor (1.5
ounces), or binge-drinking

- Recent inflammatory diseases (for example: rheumatoid arthritis, lupus)

- Cigarette smoking, use of nicotine replacement products, or smoking of
marijuana/consumption of edibles in past 3 months or during the course of the study

- History of stomach or bowel resection (other than appendectomy), gastric bypass or
other bariatric weight loss procedure

- Cancer of any type (except for non-melanoma skin) in past 3 yrs or actively using
cancer chemotherapeutic agents

- Clotting/bleeding disorders or ongoing anticoagulant use

- Bilateral mastectomy with nodal dissection

- No social security number (unable to pay stipend)

- Blood biochemistries outside of normal range

- Prior participation in a study involving berry supplementation at our institution