Study to Assess Enobosarm (GTx-024) in Postmenopausal Women With Stress Urinary Incontinence

Key Inclusion Criteria:

- SUI symptoms of at least 6 months duration

- Predominant SUI as determined at the Screening Visit using the Medical,
Epidemiological, and Social Aspects of Aging (MESA) urinary questionnaire.

- 24-Hour pad weight > 3 g during the screening period

- A minimum of 1 and no more than 15 SUI episodes on any single day AND no fewer than 9
total SUI episodes over 3 days during the screening period

- Positive bladder stress test conducted during the Screening Visit

Key Exclusion Criteria:

- History of pelvic radiation treatment

- History of urethral diverticula

- History of urethral sling or anterior prolapse repair

- Treatment with urethral bulking agents and/or other SUI procedure or surgery within
the 6 months prior to the Screening Visit

- Known vesicoureteral reflux, vaginal prolapse beyond the introitus, or other
significant pelvic floor abnormalities

- Urinary incontinence of neurogenic etiology

- Morbidly obese (defined as 100 pounds over ideal body weight, or body mass index 40 or
greater)

- Chronic hepatitis

- Hepatic cirrhosis

- Evidence of active infection with hepatitis B or hepatitis C

- History of human immunodeficiency virus (HIV) infection

- Subjects with a history of breast or endometrial cancer