IN-TANDEM Familial Hypercholesterolemia Pilot Study

Status:	Completed
Conditions:	High Cholesterol
Therapuetic Areas:	Cardiology / Vascular Diseases
Healthy:	No
Age Range:	18 - Any
Updated:	3/2/2019
Start Date:	July 20, 2017
End Date:	November 7, 2018

INTegrating Active Case-finding With Next-generation Sequencing for Diagnosis Through Electronic Medical Records (IN-TANDEM): Familial Hypercholesterolemia Pilot Study

The purpose of this study is to validate the use of the FH Foundation FIND FH® Algorithm as a
clinical decision support tool. FIND FH (Flag/Identify/Network/Engage) is a national
initiative that utilizes machine learning and data mining techniques to identify individuals
whose profiles are consistent with FH patients. The algorithm will be tested in adults with
at least one cardiovascular comorbidity. Study subjects will be asked to provide either a
saliva, buccal or venous blood sample for DNA and biomarker analysis

Inclusion Criteria:

- Age 18 years or older

- At least one cardiovascular co-morbidity or receiving treatment for a cardiovascular
comorbidity

- Algorithm score 0-1

- Most recent encounter with a provider within five years of query date

Exclusion Criteria:

- Any medical or psychological conditions that, in the opinion of the investigator,
would compromise the subject's safety or successful participation in the study, or
confound study data

We found this trial at

sites

Univ of Pennsylvania

3451 Walnut St
Philadelphia, Pennsylvania 19104

1 (215) 898-5000