Pivotal Study to Evaluate the Safety and Efficacy of GelrinC for Treatment of Cartilage Defects

Main Inclusion Criteria:

- Age between 18 and 50.

- Single contained symptomatic lesion located on the femoral condyle of the femur graded
as ICRS III or IV with less than 5 mm of bone loss below the subchondral plate.

- Lesion size between 1 and 5 cm2 post debridement, less than or equal to 2.5 cm in
diameter.

- BMI ≤35

- Contralateral knee is asymptomatic, stable, fully functional and not medically
treated.

Main Exclusion Criteria:

- Presence of an additional grade III or IV symptomatic lesion.

- Recent Osteochondritis Dissecans within 1 year of baseline visit.

- Untreated ACL and/or PCL deficiency or Complex ligamentous instability of the knee.

- Patient is excluded if presenting untreated current meniscal tear or if previous
menisci resection was within the last 6 months.

- Previous tendon repair or ligament reconstruction within the last 6 months.

- Failed Mosaicplasty or ACI or MACI or any other cartilage repair product.

- Microfracture performed less than 1 year before baseline visit.