Neural Correlates of Reward and Symptom Expression in Anorexia Nervosa
| Status: | Recruiting |
|---|---|
| Conditions: | Psychiatric, Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 3/27/2019 |
| Start Date: | February 28, 2018 |
| End Date: | August 2022 |
| Contact: | Jessie Dzombak |
| Email: | jdzombak@umn.edu |
| Phone: | 612-273-9302 |
The objective of this study is to identify the patterns of brain activity in reward circuitry
that promote symptoms of anorexia nervosa. This project will compare weight-restored
individuals with anorexia nervosa to a non-eating disorder control group on reward brain
circuitry patterns in response to typically rewarding cues (i.e., entertaining videos) and
disorder-specific restrictive eating cues (i.e., low-fat food choice) using fMRI. In
addition, this study will examine which neurobiological reward responses among
weight-restored individuals with anorexia nervosa predict objective restrictive eating
(measured by laboratory meal intake) and longitudinal risk of relapse one year later.
that promote symptoms of anorexia nervosa. This project will compare weight-restored
individuals with anorexia nervosa to a non-eating disorder control group on reward brain
circuitry patterns in response to typically rewarding cues (i.e., entertaining videos) and
disorder-specific restrictive eating cues (i.e., low-fat food choice) using fMRI. In
addition, this study will examine which neurobiological reward responses among
weight-restored individuals with anorexia nervosa predict objective restrictive eating
(measured by laboratory meal intake) and longitudinal risk of relapse one year later.
Aim 1: To compare patterns of brain activity in reward circuits to typically rewarding cues
and disorder-specific cues between weight-restored individuals with anorexia nervosa and
non-eating disorder controls
Hypothesis 1a: Activity in reward circuitry will be elevated in response to typically
rewarding cues in the non-eating disorder control group versus weight-restored anorexia
nervosa group.
Hypothesis 1b: Activity in reward circuitry will be elevated in response to disorder-specific
in the weight-restored anorexia nervosa group versus the non-eating disorder control group.
Aim 2: To specify the relationship between brain patterns related to reward and restrictive
eating among weight-restored individuals with anorexia nervosa
Hypothesis 2a: Lower reward circuit activity in response to typically rewarding cues will
predict lower test meal intake for weight-restored anorexia nervosa group versus the
non-eating disorder control group.
Hypothesis 2b: Higher reward circuit activity in response to disorder-specific cues will
predict lower test meal intake for the weight-restored anorexia nervosa group versus the
non-eating disorder control group.
Aim 3: To identify the brain patterns in reward circuitry associated with the risk of relapse
among weight-restored individuals with anorexia nervosa in the year following
weight-restoration.
Hypothesis 3a: Lower reward circuit activity in response to typically rewarding cues will
predict relapse in the weight-restored anorexia nervosa group.
Hypothesis 3b: Higher reward circuit activity in response to disorder-specific cues will
predict relapse in the weight-restored anorexia nervosa group.
and disorder-specific cues between weight-restored individuals with anorexia nervosa and
non-eating disorder controls
Hypothesis 1a: Activity in reward circuitry will be elevated in response to typically
rewarding cues in the non-eating disorder control group versus weight-restored anorexia
nervosa group.
Hypothesis 1b: Activity in reward circuitry will be elevated in response to disorder-specific
in the weight-restored anorexia nervosa group versus the non-eating disorder control group.
Aim 2: To specify the relationship between brain patterns related to reward and restrictive
eating among weight-restored individuals with anorexia nervosa
Hypothesis 2a: Lower reward circuit activity in response to typically rewarding cues will
predict lower test meal intake for weight-restored anorexia nervosa group versus the
non-eating disorder control group.
Hypothesis 2b: Higher reward circuit activity in response to disorder-specific cues will
predict lower test meal intake for the weight-restored anorexia nervosa group versus the
non-eating disorder control group.
Aim 3: To identify the brain patterns in reward circuitry associated with the risk of relapse
among weight-restored individuals with anorexia nervosa in the year following
weight-restoration.
Hypothesis 3a: Lower reward circuit activity in response to typically rewarding cues will
predict relapse in the weight-restored anorexia nervosa group.
Hypothesis 3b: Higher reward circuit activity in response to disorder-specific cues will
predict relapse in the weight-restored anorexia nervosa group.
Inclusion Criteria:
- Age > 18 years old
- Current BMI > 18.5 kg/m2
- Ability to read and speak in English
- Right-handed
- Weight restored Anorexia Nervosa group: 1) DSM-5 diagnosis of AN in the past 6 months,
with the exception of body image disturbance and intense fear of weight gain criteria;
2) BMI < 18.5 kg/m2 within past 6 months
Exclusion Criteria:
- Medical instability or current pregnancy
- Current substance use disorder, psychosis, or bipolar-I disorder
- Contraindication for fMRI
- History of neurological disorder/injury (e.g., stroke; head injury with > 10 minutes
loss of consciousness)
- Food allergy that cannot be accommodated through substitutions to the laboratory test
meal
- Lacking capacity to consent
- Non-eating disorder Control group: Current DSM-5 Axis-I diagnosis or current or past
eating disorder diagnosis
We found this trial at
1
site
Minneapolis, Minnesota 55455
(612) 625-5000
Principal Investigator: Ann Haynos, PhD
Phone: 612-273-9302
Univ of Minnesota With a flagship campus in the heart of the Twin Cities, and...
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