Proton RT for the Treatment of Pediatric Rhabdomyosarcoma

- A special device is made for each participant to help them hold still during the
treatment. This may be in the form of a mask or a custom made foam cradle depending on
the area to be treated.

- Radiation treatments will be given once per day, 5 days a week for a total of 4 to 6
weeks, depending upon how much total dose the tumor requires.

- Participants will be seen once per week by their radiation doctor to monitor health and
record any side effects from treatment.

- After the radiation treatments are completed, participants will be required to undergo
further tests and evaluations for several years following treatment.

Inclusion Criteria:

- Patients with biopsy proven newly diagnosed rhabdomyosarcoma.

- Patients less than or equal to 21 years of age.

- Patients must be treated with a standardly accepted chemotherapy regimen.

- May not have metastatic disease unless aged 2-10 with embryonal histology.

- Must be willing to receive follow-up care for a minimum of five years after treatment
at MGH and annual visits unless it is too difficult to return to MGH for follow-up
care. In that event, they must be willing to have their outside medical information
released to us to track the results.

- Timing of radiation must be according to the IRB protocol upon which the patient is
treated within either 35 days of last chemotherapy or surgery.

Exclusion Criteria:

- Life expectancy of less than 2 years.

- Co-morbidities that would make the use of radiation too toxic to deliver safely, such
as serious local injury or collagen vascular disease.

- Patients who are pregnant

- Previous treatment with radiation therapy.