VL-2397 Compared to Standard First-Line Treatment for Invasive Aspergillosis (IA) in Adults



Status:Terminated
Conditions:Pulmonary
Therapuetic Areas:Pulmonary / Respiratory Diseases
Healthy:No
Age Range:18 - Any
Updated:3/1/2019
Start Date:February 20, 2018
End Date:January 14, 2019

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Trial Summary
Trial Overview
Inclusion Criteria

A Phase 2 Study of VL-2397 Compared to Standard First-Line Treatment for Invasive Aspergillosis in Adults With Acute Myelogenous Leukemia, Acute Lymphocytic Leukemia, or Allogeneic Hematopoietic Cell Transplant Recipients

The purpose of the trial is to evaluate the safety and efficacy of a new antifungal with a
novel mechanism of action in immunocompromised adults with invasive aspergillosis.

To compare the safety and efficacy of VL-2397 to standard first-line treatment for invasive
aspergillosis in immunocompromised adults with acute leukemia or recipients of an allogeneic
hematopoietic cell transplant (allo-HCT).

Inclusion Criteria:

- Acute Leukemia (AML or ALL) patient or allo-HCT recipient with a diagnosis of IA

Exclusion Criteria:

- Pregnant or breastfeeding

- IA involving sites other than lungs and sinuses

- Graft failure, acute or extensive chronic GvHD

- Uncontrolled diabetes
We found this trial at
12
sites
Fred Hutchinson Cancer Research Center (FHCRC)
Seattle, Washington 98109
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Medical College of Georgia; Augusta University
1120 15th Street
Augusta, Georgia 30909
Phone: 706-721-0309
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Augusta, GA
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University of Alabama at Birmingham Hospital, Division of Infectious Diseases
Birmingham, Alabama 35233
Phone: 205-934-9662
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Birmingham, AL
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DMC - Harper University Hospital
Detroit, Michigan 48201
Phone: 313-993-0253
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Detroit, MI
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University Hospital Antwerp (UZA), Department of Hematology
Edegem, Antwerp
Phone: +32 3 821 53 98
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Edegem,
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The University of Texas Health Science Center, Department of Internal Medicine
Houston, Texas 77030
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Houston, TX
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UC San Diego Moores Cancer Center
3855 Health Sciences Dr,
La Jolla, California 92093
(858) 822-6100
Phone: 858-822-5364
UC San Diego Moores Cancer Center Established in 1978, UC San Diego Moores Cancer Center...
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La Jolla, CA
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Medical College of Wisconsin
8701 W Watertown Plank Rd
Milwaukee, Wisconsin
(414) 955-8296
Phone: 414-955-0492
Medical College of Wisconsin The Medical College (MCW) of Wisconsin is a major national research...
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Milwaukee, WI
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University of Minnesota Department of Medicine
2101 6th Street Southeast
Minneapolis, Minnesota 55455
Phone: 612-626-3798
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Minneapolis, MN
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Christiana Care Health Services, Department of Medicine
Newark, Delaware 19718
Phone: 1-302-733-4164
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Newark, DE
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UC Davis Health, Dept. of Internal Medicine, Div. of Infectious Diseases
Sacramento, California 95817
Phone: 916-734-8033
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Sacramento, CA
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Washington University School of Medicine, Division of Infectious Disease
Saint Louis, Missouri 63110
Phone: 314-747-1922
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Saint Louis, MO
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