Skeletal Health in Bariatric Surgery Patients
| Status: | Recruiting |
|---|---|
| Conditions: | Osteoporosis, Orthopedic, Women's Studies |
| Therapuetic Areas: | Rheumatology, Orthopedics / Podiatry, Reproductive |
| Healthy: | No |
| Age Range: | 19 - Any |
| Updated: | 2/6/2019 |
| Start Date: | March 22, 2018 |
| End Date: | October 2, 2020 |
| Contact: | Amandiy N Liwo, MD,MSPH |
| Email: | amandiyliwo@uabmc.edu |
| Phone: | 205-996-5186 |
The investigators propose a prospective cohort trial that will help to understand the impact
of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) in pre- and post-menopausal
female bariatric patients.
of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) in pre- and post-menopausal
female bariatric patients.
While highly effective both RYGB and SG may lead to increased bone resorption, decreased bone
mass, and increased risk of some fractures. Very few studies have compared the effects of the
RYGB and the SG on changes skeletal health and findings have been inconsistent. Furthermore,
few studies have investigated the short- or long-term consequences of bariatric surgery on
bone mineral density in pre- and post-menopausal women. To what extent and how bariatric
surgery impacts the skeleton largely remains undetermined. Because estrogen is protective
against osteoporosis and fractures, the majority of fractures occur in postmenopausal women.
It is important that women have higher rates of obesity (38.3%) compared to men (34.3%) and
that ≥67% of bariatric patients are women. Therefore, women may be at a significantly
increased risk of developing osteoporosis. These data may help establish clinical guidelines
to assess, maintain, and promote skeletal health in the preoperative and postoperative care
of bariatric patients; and it may help to determine the appropriate bariatric procedure for
women at risk of osteoporosis and fractures.
mass, and increased risk of some fractures. Very few studies have compared the effects of the
RYGB and the SG on changes skeletal health and findings have been inconsistent. Furthermore,
few studies have investigated the short- or long-term consequences of bariatric surgery on
bone mineral density in pre- and post-menopausal women. To what extent and how bariatric
surgery impacts the skeleton largely remains undetermined. Because estrogen is protective
against osteoporosis and fractures, the majority of fractures occur in postmenopausal women.
It is important that women have higher rates of obesity (38.3%) compared to men (34.3%) and
that ≥67% of bariatric patients are women. Therefore, women may be at a significantly
increased risk of developing osteoporosis. These data may help establish clinical guidelines
to assess, maintain, and promote skeletal health in the preoperative and postoperative care
of bariatric patients; and it may help to determine the appropriate bariatric procedure for
women at risk of osteoporosis and fractures.
Inclusion Criteria:
- Adult females ≥ 19 years scheduled to undergo bariatric surgery (Roux en Y Gastric
Bypass or Gastric Sleeve Surgery)
- Class II (BMI 35-39.9 kg/m2).
- Class III obesity (BMI ≥ 40 kg/m2).
- Scheduled to undergo bariatric surgery with the ability to provide informed consent.
Exclusion Criteria:
- Patients with a history of thyroid disorders, thyroidectomy and levothyroxine use.
- Patients with a history of known osteoporosis, steroid-induced osteoporosis, current
or previous use of medications for osteoporosis.
- Patients with a history of gastrointestinal malabsorption.
- Patients with a history of renal diseases.
- Patients with a history of current or previous use of corticosteroids.
- Patients who have used tobacco products within a year of study enrollment.
- Patients with surgically-induced menopause e.g. bilateral salpingo-oophorectomy.
- Patients with a history of breast cancer, who have had or are currently on hormonal
therapy or anti-hormonal therapy.
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