Hyperbaric Oxygen and Manipulative Therapies to Regain Function Post Stroke

The primary objective of this study is to show that hyperbaric oxygen therapy combined with
osteopathic manipulative therapies improve outcomes in patients who have persistent
neurological deficits after ischemic stroke compared to historical norms.

The secondary objectives of this study is to demonstrate safety and feasibility of treating
patients post stroke with hyperbaric oxygen and osteopathic therapies as well as determine
improvements in multiple assessment scales of motor function, depression, activities of daily
living(ADL) and pain

Inclusion Criteria:

1. Post Ischemic stroke

2. Patients aged 18-80

3. NIHSS >5

4. mRS>/=3, which connotes moderate disability requiring some help.

5. Persistent significant motor dysfunction of at least one arm

6. Subacute stroke patients (within three months from time of stroke)

7. Chronic stroke patients (more than 6months from time of stroke)

8. Patient must be able to understand instructions and verbalize discomfort

9. Reliable attendance for daily (M-F) HBOT treatment and 2x/week OMT sessions for up to
6weeks

Exclusion Criteria:

1. Hemorrhagic stroke

2. Prior functional disability mRS >1

3. Expressive or receptive aphasia

4. Bedbound patients due to lifting limitations for HBOT

5. History of severe, advanced emphysema with bullous disease

6. Prior history of spontaneous pneumothorax or chest surgery

7. Prior history of depression requiring medications

8. Pregnancy

9. Concomitant non-conventional rehab therapies including: acupuncture, botulinum toxin
injections, massage therapy

10. Significant claustrophobia