Rucaparib in Patients With Locally Advanced or Metastatic Urothelial Carcinoma



Status:Recruiting
Conditions:Prostate Cancer, Cancer, Cancer, Cancer, Cancer, Cancer, Bladder Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:4/6/2019
Start Date:June 1, 2018
End Date:June 2020
Contact:Clovis Oncology Clinical Trial Navigation
Email:clovistrials@emergingmed.com
Phone:1-855-262-3040 (USA)

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Trial Summary
Trial Overview
Inclusion Criteria

A Phase 2, Open-label Study of Rucaparib in Patients With Locally Advanced or Metastatic Urothelial Carcinoma

The purpose of the ATLAS study is to determine how patients with locally advanced
unresectable or metastatic urothelial carcinoma respond to treatment with rucaparib.


Inclusion Criteria:

- Have histologically or cytologically confirmed locally advanced unresectable or
metastatic transitional cell carcinoma of the urothelium (renal pelvis, ureter,
urinary bladder or urethra)

- Received 1 or 2 prior treatment regimens for advanced or metastatic disease

- Confirmed radiologic disease progression during or following recent treatment

- Mandatory biopsy is required during screening

- Measurable disease per RECIST v1.1

- Adequate organ function

- ECOG 0 or 1

Exclusion Criteria:

- Prior treatment with a PARP inhibitor

- Symptomatic and/or untreated CNS metastases

- Duodenal stent and/or any gastrointestinal disorder that may interfere with absorption
of rucaparib
We found this trial at
42
sites
Penn State Hershey Medical Center
Hershey, Pennsylvania 17033
Phone: 855-262-3040
337
mi
from 43215
Hershey, PA
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Roswell Park Cancer Institute
666 Elm Street
Buffalo, New York 14263
(716) 845-2300
Phone: 855-262-3040
Roswell Park Cancer Institute Welcome to Roswell Park Cancer Institute (RPCI), America's first cancer center...
295
mi
from 43215
Buffalo, NY
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Providence Portland Medical Center
4805 Northeast Glisan Street
Portland, Oregon 97213
(503) 215-1111
Phone: 855-262-3040
Providence Portland Medical Center We strive to give those we serve exceptional, compassionate health care...
2026
mi
from 43215
Portland, OR
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Oregon Health and Science University
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
Phone: 855-262-3040
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
2026
mi
from 43215
Portland, OR
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Stanford University School of Medicine
291 Campus Dr
Stanford, California 94305
(650) 725-3900
Phone: 855-262-3040
Stanford University School of Medicine Vast in both its physical scale and its impact on...
2100
mi
from 43215
Stanford, CA
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New York Oncology Hematology, P.C. (USO - US Oncology)
Albany, New York 12208
Phone: 855-262-3040
?
mi
from 43215
Albany, NY
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University of New Mexico UNM Cancer Research and Treatment Center
Albuquerque, New Mexico 87102
Phone: 855-262-3040
?
mi
from 43215
Albuquerque, NM
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Lehigh Valley Health Network
Allentown, Pennsylvania 18105
Phone: 855-262-3040
400
mi
from 43215
Allentown, PA
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University of Michigan
500 S State St
Ann Arbor, Michigan 48109
(734) 764-1817
Phone: 855-262-3040
University of Michigan The University of Michigan was founded in 1817 as one of the...
164
mi
from 43215
Ann Arbor, MI
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University of Maryland/Marlene and Stewart Greenebaum Cancer Center
Baltimore, Maryland 21201
Phone: 855-262-3040
343
mi
from 43215
Baltimore, MD
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University of Virginia, Emily Couric Clinical Center
Charlottesville, Virginia 22908
?
mi
from 43215
Charlottesville, VA
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University Oncology & Hematology
Chattanooga, Tennessee 37403
?
mi
from 43215
Chattanooga, TN
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Northwestern University Chicago
Chicago, Illinois 60611
Phone: 855-262-3040
274
mi
from 43215
Chicago, IL
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Texas Oncology PA (USO - US Oncology)
Dallas, Texas 76201
Phone: 855-262-3040
?
mi
from 43215
Dallas, TX
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Duke University, Duke Cancer Institute
Durham, North Carolina 27710
Phone: 855-262-3040
?
mi
from 43215
Durham, NC
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John Theurer Cancer Center at the Hackensack University Medical Center
92 2nd St
Hackensack, New Jersey 07601
(201) 996-5900
Phone: 855-262-3040
John Theurer Cancer Center at the Hackensack University Medical Center The mission of the John...
476
mi
from 43215
Hackensack, NJ
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Hartford Health Care Cancer Institute
80 Seymour Street
Hartford, Connecticut 06102
Phone: 855-262-3040
554
mi
from 43215
Hartford, CT
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University of Texas, UT Health Science Center
Houston, Texas 77030
Phone: 855-262-3040
?
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from 43215
Houston, TX
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Indiana University Melvin and Bren Simon Cancer Center (IUSCC)
Indianapolis, Indiana 46202
Phone: 855-262-3040
167
mi
from 43215
Indianapolis, IN
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University of Iowa - Holden Comprehensive Cancer Center
Iowa City, Iowa 52242
Phone: 855-262-3040
460
mi
from 43215
Iowa City, IA
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University of California San Diego UCSD Moores Cancer Center
La Jolla, California 92093
Phone: 855-262-3040
1953
mi
from 43215
La Jolla, CA
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Comprehensive Cancer Centers of Nevada (CCCN)
Las Vegas, Nevada 89169
Phone: 855-262-3040
1756
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from 43215
Las Vegas, NV
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University of California at Los Angeles - UCLA
Los Angeles, California 90095
Phone: 855-262-3040
1982
mi
from 43215
Los Angeles, CA
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Norton Cancer Center
Louisville, Kentucky 40202
Phone: 855-262-3040
188
mi
from 43215
Louisville, KY
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Centre de Lutte Contre le Cancer (CLCC) - Universite de Lyon - Centre Leon-Berard
Lyon, 69008
Phone: 855-262-3040
?
mi
from 43215
Lyon,
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Miami Cancer Institute Baptist Health South Florida
Miami, Florida 33143
Phone: 855-262-3040
997
mi
from 43215
Miami, FL
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Froedtert and the Medical College of Wisconsin
9200 W Wisconsin Ave
Milwaukee, Wisconsin 53226
(414) 805-3666
Phone: 855-262-3040
Froedtert and the Medical College of Wisconsin Froedtert Health combines with the Medical College of...
335
mi
from 43215
Milwaukee, WI
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Minnesota Oncology Hematology P.A. (USO - US Oncology)
Minneapolis, Minnesota 55404
Phone: 855-262-3040
?
mi
from 43215
Minneapolis, MN
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Atlantic Urology Clinics
Myrtle Beach, South Carolina 29572
Phone: 855-262-3040
490
mi
from 43215
Myrtle Beach, SC
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Urology Associates
Nashville, Tennessee 37209
Phone: 855-262-3040
335
mi
from 43215
Nashville, TN
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Ochsner Cancer Institute
New Orleans, Louisiana 70121
Phone: 855-262-3040
799
mi
from 43215
New Orleans, LA
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Memorial Sloan Kettering Cancer Center
1275 York Ave
New York, New York 10021
(212) 639-2000
Phone: 855-262-3040
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
480
mi
from 43215
New York, NY
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New York Presbyterian Hospital-Weill Cornell Medical Center
New York, New York 10021
Phone: 855-262-3040
480
mi
from 43215
New York, NY
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Eastern Connecticut Hematology/ Oncology Associates (ECHO)
Norwich, Connecticut 06360
Phone: 855-262-3040
582
mi
from 43215
Norwich, CT
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Stephenson Cancer Center
Oklahoma City, Oklahoma 73104
Phone: 855-262-3040
?
mi
from 43215
Oklahoma City, OK
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Universityof California, Irvine
Orange, California 92868
Phone: 855-262-3040
?
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from 43215
Orange, CA
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Northwest Cancer Specialists P.C. (USO - US Oncology)
Portland, Oregon 97062
Phone: 855-262-3040
?
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from 43215
Portland, OR
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University of Utah, Huntsman Cancer Institute
Salt Lake City, Utah 84112
Phone: 855-262-3040
1511
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from 43215
Salt Lake City, UT
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Saint John's Health Center - John Wayne Cancer Institute (JWCI)
Santa Monica, California 90404
?
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from 43215
Santa Monica, CA
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Pinnacle Oncology, Honor Health
Scottsdale, Arizona 85258
Phone: 855-262-3040
?
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from 43215
Scottsdale, AZ
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University of Washington/Seattle Cancer Care Alliance
Seattle, Washington 98109
Phone: 855-262-3040
2007
mi
from 43215
Seattle, WA
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Medstar Georgetown University Medical Center
Washington, District of Columbia 20007
Phone: 855-262-3040
325
mi
from 43215
Washington,
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