Alternatives for Reducing Tics in TS: A Study of TEV-50717 (Deutetrabenazine) for the Treatment of Tourette Syndrome in Children and Adolescents.

Inclusion Criteria:

- Patient is 6 to 16 years of age, inclusive

- Patient weighs at least 44 pounds (20 kg)

- The patient's active tics are causing distress or impairment

- Patient is able to swallow study medication whole

- Patient is in good general health

- Women/girls of childbearing potential whose male partners are of childbearing
potential must use contraception for the duration of the study

- Additional criteria apply, please contact the investigator for more information

Exclusion Criteria:

- Patient has a neurologic disorder other than Tourette syndrome (TS) that could obscure
the evaluation of tics.

- Patient has a confirmed diagnosis of bipolar disorder, schizophrenia, or another
psychotic disorder.

- Patient has clinically significant depression at screening or baseline.

- Patient has a history of suicidal intent or related behaviors within 2 years of
screening.

- Patient has a history of a previous actual, interrupted, or aborted suicide attempt.

- Patient has a first-degree relative who has completed suicide.

- Patient has received comprehensive behavioral intervention for tics (CBIT) for TS or
cognitive behavioral therapy (CBT) for obsessive-compulsive disorder (OCD) within 4
weeks of screening.

- Patient has an unstable or serious medical illness at screening or baseline.

- Patient is pregnant or breastfeeding.

- Additional criteria apply, please contact the investigator for more information.