Nitrate Supplementation and Muscle Blood Flow
| Status: | Completed |
|---|---|
| Conditions: | Healthy Studies, High Blood Pressure (Hypertension), Hematology |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Hematology, Other |
| Healthy: | No |
| Age Range: | 60 - 80 |
| Updated: | 1/11/2019 |
| Start Date: | October 10, 2017 |
| End Date: | February 8, 2018 |
Nitric Oxide Bioavailability and Dynamics of Blood Flow and Vasodilation With Age
The main purpose of this study is to evaluate the effects of an acute dose of dietary nitrate
in the form of beetroot juice on skeletal muscle blood flow in response to dynamic knee
extension exercise in healthy older adults. All subjects will receive active (rich in dietary
nitrate) or placebo (devoid of nitrate) supplementation.
in the form of beetroot juice on skeletal muscle blood flow in response to dynamic knee
extension exercise in healthy older adults. All subjects will receive active (rich in dietary
nitrate) or placebo (devoid of nitrate) supplementation.
Dietary nitrate (beetroot juice) is reduced to nitrite and nitric oxide within the digestive
system of humans. Nitric oxide exerts potent vasodilator effects, which have been shown to
reduce blood pressure and enhance exercise economy in humans. This pressure reducing effect
may have implications within the regulation of blood flow during dynamic exercise in older
adults.
system of humans. Nitric oxide exerts potent vasodilator effects, which have been shown to
reduce blood pressure and enhance exercise economy in humans. This pressure reducing effect
may have implications within the regulation of blood flow during dynamic exercise in older
adults.
Inclusion Criteria:
- Healthy older adults 60-80 years of age
Exclusion Criteria:
- Hypertension,
- Smoking,
- Heart disease,
- Diabetes,
- Body mass index (BMI) ≥ 30 kg/m2,
- Autonomic disorders and other conditions that may alter blood pressure or vascular
function
- Medications that might normally alter blood pressure or vascular function.
- Older women taking hormone replacement therapy medications.
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