Safety Study of LLF580 in Obese Volunteers

Inclusion Criteria:

- Body mass index (BMI) within the range of 30 to 45 kg/m2, inclusive, with ethnic
adjustment (≥27.5 kg/m2 for Asian individuals).

- Fasting triglyceride 150 - 500 mg/dL (1.69 - 5.65 mmol/L), inclusive, at screening.

- Able to communicate well with the investigator, to understand and comply with the
requirements of the study.

Exclusion Criteria:

- History of hepatobilliary disease.

- Liver disease or liver injury as indicated by abnormal liver function tests.

- Chronic infection with Human Immunodeficiency Virus (HIV), Hepatitis B (HBV) or
Hepatitis C (HCV).

- Fasting triglycerides greater than or equal to 500 mg/dL [5.65 mmol/L], or concomitant
use of drug treatment for hypertriglyceridemia (fibrates, omega-3 fatty acids,
nicotinic acid).

- History of pancreatic injury or pancreatitis.

- History of hypersensitivity to drugs of similar biological class, FGF21 protein
analogue, or Fc fusion proteins.

- History of bone disorders or low vitamin D level.

- Contraindications to MRI.

- Change in body weight (more than 5% self-reported OR 5 kg self-reported change during
the previous 3 months).

- Use of weight loss drugs.

- Enrollment in a diet, weight loss or exercise programs.