A Study of the Relationship of Gut Microbial Composition and Stroke Outcome
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Peripheral Vascular Disease, Neurology |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Neurology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/17/2018 |
| Start Date: | December 6, 2017 |
| End Date: | July 1, 2022 |
The purpose of this pilot study is to investigate the relationship between gut microbial
composition and stroke outcome. If we can establish a relationship between gastrointestinal
microbial community composition and convalescent ischemic stroke outcomes in a U.S. sample,
such results would prompt further mechanistic studies, and ultimately provide a rationale for
trials to determine whether modulating intestinal immune responses (e.g. via prebiotic,
probiotic, or fecal transfer methods) would be beneficial.
composition and stroke outcome. If we can establish a relationship between gastrointestinal
microbial community composition and convalescent ischemic stroke outcomes in a U.S. sample,
such results would prompt further mechanistic studies, and ultimately provide a rationale for
trials to determine whether modulating intestinal immune responses (e.g. via prebiotic,
probiotic, or fecal transfer methods) would be beneficial.
Inclusion Criteria:
1. Men and women at least 18 years of age.
2. Willing and able to attend all study visits.
3. English speaking.
4. Must have had a stroke or TIA that occurred within 48 hours of admission to the UVA
Stroke Unit as determined by a vascular neurologist.
Exclusion Criteria:
1. History of inflammatory bowel disease.
2. Receiving antibiotics within 30 days of entry into the study.
3. History of institutionalization for mental illness.
4. Unable to consent and does not have a surrogate available to consent on their behalf.
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University of Virginia Health System UVA Health System includes a 604-bed hospital, level I trauma...
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