Effects of THC on Emotional Memory Retrieval

Here, the investigators aimed to investigate the effects of THC (15 mg) on the retrieval of
negative, neutral, and positive memories. The study used a placebo-controlled,
within-subjects, crossover design with 23 participants. In each experimental arm,
participants attend a session to encode stimuli and a second session 48 hours later in which
their memories are tested for the stimuli from the first session. In the second session, two
hours prior to memory testing, THC or placebo is administered. On all sessions subjects
complete mood questionnaires.

Inclusion Criteria:

- 4-100 lifetime cannabis occasions

Exclusion Criteria:

- Current Axis I DSM-IV disorder, including substance dependence, current use of >5
cigarettes per day, history of psychosis or mania, less than a high school education,
lack of English fluency, a body mass index outside 19-33 kg/m2, high blood pressure
(>140/90), abnormal electrocardiogram, daily use of any medication other than birth
control, pregnancy, or lactating.