Rheumatoid Arthritis Comorbidity: Bone Health in Men and African Americans
| Status: | Completed |
|---|---|
| Conditions: | Arthritis, Rheumatoid Arthritis |
| Therapuetic Areas: | Rheumatology |
| Healthy: | No |
| Age Range: | 19 - Any |
| Updated: | 5/27/2013 |
| Start Date: | July 2004 |
| End Date: | July 2010 |
| Contact: | Ted R Mikuls, MD, MSPH |
| Email: | tmikuls@unmc.edu |
| Phone: | 402-559-7258 |
RA Comorbidity: Bone Health in Men and African Americans
The objective of the proposed study is to assess bone health and determinants of bone health
among select subpopulations of rheumatoid arthritis patients.
The overall hypothesis of this study is that osteopenia and/or osteoporosis are common among
African Americans and men with rheumatoid arthritis and there are identifiable genetic and
environmental factors contributing to the pathogenesis of bone loss in these groups.
The Specific Aims of the study are to:
1. Determine baseline hip and lumbar spine bone density (BMD) values and
osteopenia/osteoporosis prevalence among African American men and women with early RA
and among male veterans with established RA.
2. Identify environmental factors and candidate alleles, which confer increased risk of
reduced baseline BMD loss over time among African American men and women with early RA
and among male veterans with established RA.
Inclusion Criteria:
- Clinical diagnosis of rheumatoid arthritis per ACR guidelines
Exclusion Criteria:
- Patients with diagnosis > 2yrs (CLEAR study)
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