New Non-invasive Modalities for Assessing Retinal Structure and Function

Controls:

Inclusion:

Normal eye exam in last 2 years

Exclusion:

Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are
okay. Any abnormalities of the retina or optic nerve that could affect metabolism of the
retina outside of normal.

Subjects with Inner Retina Defect:

Inclusion:

Defined structural defect to include those with Ischemic optic neuropathy, branch retinal
artery occlusion (BRAO), hemianopia or visual field defect that respects the vertical
meridian, inherited mitochondrial optic neuropathies such as Leber's and Dominant Optic
Neuropathy, other retinopathies or optic neuropathies.

Exclusion:

Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are
okay.

Subjects with Outer Retinal Defect:

Inclusion:

AZOOR (acute zonal occult outer retinopathy) or other focal or diffuse outer photoreceptor
loss of function

Exclusion:

Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are
okay.

The 450 total is to allow for exclusion of some subjects or in the event that the enrolled
subject blinks too much or cannot fixate on a visual target adequately to maintain the same
eye position during the short imaging interval. We hope to have a total of 450 (50 controls
and 400 patients)