Perfusion Enhancement With Respiratory Impedance in Stroke (PERI-Stroke)

Inclusion Criteria:

1. Age > 18 years

2. Ability and willingness to sign informed consent by patient or legally acceptable
surrogate decision maker

3. Acute ischemic stroke within 72 hours of study enrollment

4. Imaging or examination confirming unilateral frontal lobe involvement in the stroke

Exclusion Criteria:

1. Hemorrhagic conversion of ischemic infarct

2. History or presence of congestive heart failure, as defined by any of the following:

1. Any preceding diagnosis of congestive heart failure as per patient report or
medical record

2. Report of moderate or severe systolic or diastolic dysfunction on prior

3. Reduced ejection fraction, <50%, on prior echocardiogram

4. Jugular venous pulsations >10 cm

5. Pulmonary edema on chest radiography Of note, an echocardiogram is not required
prior to study enrollment.

3. History or presence of cardiomyopathy, as per medical record, patient report, or prior
echocardiogram

4. History or presence of pneumothorax or hemothorax

5. History or presence of COPD

6. History of current use of home oxygen

7. Presence of pneumonia, as clinically determined by the primary medical team after
admission chest radiography

8. Age < 18 years

9. Skull defect that would interfere with CBF monitoring

10. Pregnancy (urine or serum testing will required prior to enrollment of any
pre-menopausal women)

11. Structural brain lesion, including known primary tumor, metastatic tumor, or vascular
malformation

12. Prior neurosurgical procedure

13. Any medical condition that the clinical investigator feels would pose a hazard to the
subject if he/she participated in the study