Antibiotics During Intrauterine Balloon Tamponade Placement

The investigators will perform a randomized, controlled trial of women who have had a
postpartum hemorrhage and received an intrauterine balloon tamponade.

Patients who are candidates for study enrollment will be identified on Labor & Delivery or in
the Maternal-Fetal Care Unit. Patients who give consent will be randomized by random number
generator to receive either antibiotics (Group A) or no antibiotics (Group B).

If the patient is randomized to Group A, she will receive a 24-hour course of antibiotics.
The primary antibiotic of choice will be cefazolin 1 gm iv q8 hours. If the patient has
contraindications to the use of cefazolin including cefazolin allergy, hypersensitivity, or
severe beta lactam allergy, then clindamycin 900 mg iv q8 hours will be used instead.

If the patient is randomized to Group B, she will not receive antibiotics as part of the
study, though if at any time her provider chooses to administer antibiotics either
prophylactically or for treatment she will not prohibited in any way from this or any other
treatment as appropriate.

Inclusion Criteria:

- Female

- Able to give consent

- Gestational age > 24 weeks

- Postpartum

- Placement of an IBT within the last 2 hours with plans for it to remain in situ for at
least 2 hours

- Primary obstetrician amenable to proceeding with either method of management during
the study period.

Exclusion Criteria:

- Age < 18 years old

- IBT removed within 2 hours of placement

- Chorioamnionitis

- Insufficient documentation of demographics, delivery outcomes, or peripartum events
including postpartum hemorrhage, infectious outcomes