Acute Effects of E-Cigarette Aerosol Inhalation
| Status: | Recruiting |
|---|---|
| Conditions: | Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - 35 |
| Updated: | 6/14/2018 |
| Start Date: | May 22, 2018 |
| End Date: | February 2021 |
| Contact: | Kelly Sexton, B.A. |
| Email: | kelly.sexton@uphs.upenn.edu |
| Phone: | 215-662-2842 |
Acute and Long-term Effects of E-Cigarette Aerosol Inhalation on Biomarkers of Endothelial Function and Vascular Reactivity
The purpose of this study is to examine the acute effects of nicotine free electronic
cigarette aerosol on vascular function in healthy, non-smokers.
This study comprises a portion of a larger study comparing results of vascular function in
nonsmokers to vascular function in healthy smokers chronically exposed to nicotinized
electronic cigarette aerosol versus conventional cigarettes.
cigarette aerosol on vascular function in healthy, non-smokers.
This study comprises a portion of a larger study comparing results of vascular function in
nonsmokers to vascular function in healthy smokers chronically exposed to nicotinized
electronic cigarette aerosol versus conventional cigarettes.
The purpose of this study is 1) to examine the acute effects of nicotine free e-cigarette
aerosol on vascular function in healthy, non-smokers and 2) to examine and compare vascular
function in healthy smokers chronically exposed, at baseline and after 12 months, to
nicotinized e-cigarette aerosol versus conventional cigarettes as compared to age, gender and
body mass index-matched nonsmokers. Vascular function (microvascular reactivity via dynamic
femoral oximetry, arterial hyperemia, femoral artery flow-mediated dilation, central
pulse-wave velocity, neurovascular reactivity) will be assessed as part of a single
integrated MRI protocol. The outcome of the project will provide new insight into the acute
and chronic effects of e-cigarette aerosol inhalation in terms of surrogate markers of
endothelial dysfunction (EDF), the prime promoter of atherosclerotic cardiovascular disease,
and aid toward establishment of future public health advisories.
aerosol on vascular function in healthy, non-smokers and 2) to examine and compare vascular
function in healthy smokers chronically exposed, at baseline and after 12 months, to
nicotinized e-cigarette aerosol versus conventional cigarettes as compared to age, gender and
body mass index-matched nonsmokers. Vascular function (microvascular reactivity via dynamic
femoral oximetry, arterial hyperemia, femoral artery flow-mediated dilation, central
pulse-wave velocity, neurovascular reactivity) will be assessed as part of a single
integrated MRI protocol. The outcome of the project will provide new insight into the acute
and chronic effects of e-cigarette aerosol inhalation in terms of surrogate markers of
endothelial dysfunction (EDF), the prime promoter of atherosclerotic cardiovascular disease,
and aid toward establishment of future public health advisories.
Inclusion Criteria:
• BMI of 18.5 - 30
Exclusion Criteria:
- Cancer
- HIV
- Mental illness
- Overt cardio- or neurovascular disease (prior heart attack, stroke, transient ischemic
attacks)
- Serious arrhythmias
- Bronchospastic disease
- Upper respiratory tract infection within the past six weeks
- Chronic medication or antibiotics
- Claustrophobia / contraindications for MRI
We found this trial at
1
site
Philadelphia, Pennsylvania 19104
Principal Investigator: Felix W Wehrli, Ph.D.
Phone: 215-662-2842
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