A Study of Fluoroquinolones Exposure and Collagen-Related Serious Adverse Events

Inclusion Criteria:

- Have evidence of at least 1 instance of Achilles Tendon Rupture (ATR) or Retinal
Detachment (RD) or Aortic Aneurysm and Dissection (AAD)

- Have at least 1 exposure to Fluoroquinolones or any of the other antibiotics
(amoxicillin, azithromycin, trimethoprim and trimethroprim/sulfamethoxazole) or
febrile illness not treated with antibiotic

- Have at least 1 year of continuous enrollment with pharmacy benefits prior to the ATR,
RD or AAD

Exclusion Criteria:

ATR, AAD and RD cohorts:

- Participants who experience the index event while within a time-at-risk window for more
than one exposure type. (The exposure types in this study include FQ as a class,
amoxicillin, azithromycin, trimethoprim, trimethroprim/sulfamethoxazole, and febrile
illness not treated with antibiotics. Events while within a time-at-risk window of two or
more exposure types cannot be associated with any one exposure. Participants are therefore
excluded from the study)

For ATR and AAD cohorts:

- Have inherited disorders of connective tissue, specifically: Ehlers-Danlos syndrome,
epidermolysis bullosa, Marfan syndrome, osteogenesis imperfecta

- Have an ATR or AAD event prior to index, during the 1-year pre-index period

For RD cohort:

- Have cataract surgery prior to index

- Have iridotomy or iridectomy prior to index